COVID-19 highlights the model dilemma in biomedical research

Nature Reviews Materials. 2021;6(5):374-376. doi: 10.1038/s41578-021-00305-z

Scientists worldwide struggle to identify suitable animal models to study SARS-CoV-2 infections. Interspecies-related differences, such as host specificity, divergent immune responses, or the unavailability of species-specific reagents hamper the research. Human-based models, such as micro-engineered multi-organs-on-chip, may hold the solution.

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