Immune/infectious disease

S. Tori Ellison, Ian Hayman, Kristy Derr, et al. Limitations of acyclovir and identification of potent HSV antivirals using 3D bioprinted human skin equivalents. Nature Communications. 2025;16(1):9200. doi:10.1038/s41467-025-64245-w

Xin Chen, Mustafa Ghanizada, Vamsee Mallajosyula, et al. Differential roles of human CD4+ and CD8+ regulatory T cells in controlling self-reactive immune responses. Nature Immunology. 2025:1-10. doi:10.1038/s41590-024-02062-x

Titilola D. Kalejaiye, Rohan Bhattacharya, Samira Musah. A Vascularized Human Organ Chip Reveals SARS-CoV-2 Susceptibility in Developmentally Guided Tissue Maturation. Cellular and Molecular Bioengineering. 2025. doi:10.1007/s12195-025-00851-4

Keitaro Kanie, Takeshi Ito, Genzo Iguchi, et al. Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid. Nature Communications. 2025;16(1):7900. doi:10.1038/s41467-025-63183-x

Angelica Medina, Yu-Chi Chen, Jiajing Zhang, et al. Modeling neurotropic virus infection with functional human neural spheroids as a platform for high-throughput antiviral screening and pathogenesis. Antiviral Research. 2025;242:106248. doi:10.1016/j.antiviral.2025.106248

Yuncheng Man, Ryan R. Posey, Haiqing Bai, et al. Preclinical assessment of pan-influenza A virus CRISPR RNA therapeutics in a human lung alveolus chip. Lab on a Chip. 2025. doi:10.1039/D5LC00156K

Andrew I. Morrison, Jonas Jäger, Charlotte M. de Winde, et al. Integration of lymphatic vasculature to a human lymph node-on-chip enhances physiological immune properties. Materials Today Bio. 2025;35:102326. doi:10.1016/j.mtbio.2025.102326

Rachel Ringquist, Eshant Bhatia, Paramita Chatterjee, et al. An immune-competent lung-on-a-chip for modelling the human severe influenza infection response. Nature Biomedical Engineering. 2025:1-23. doi:10.1038/s41551-025-01491-9

Anna Niarakis, Gary An, Luiz Ladeira, et al. Building Immune Digital Twins: An International and Transdisciplinary Community Effort. ImmunoInformatics. 2025. doi:10.1016/j.immuno.2025.100060

Jonas Jäger, Maria Thon, Katharina Schimek, Uwe Marx, Susan Gibbs, Jasper J. Koning. Differential biomarker expression of blood and lymphatic vasculature in multi-organ-chips. Scientific Reports. 2025;15(1):14492. doi:10.1038/s41598-025-96367-y