Immune/infectious disease

Anubama Rajan, Divya Nagaraj, Carolyn Bomidi, et al. Single cell sequencing analysis of respiratory syncytial virus–infected pediatric and adult human nose organoids reveals age differences, proliferative diversity and identifies novel cellular tropism. Journal of Infection. 2025;91(4). doi:10.1016/j.jinf.2025.106617

Xin Chen, Mustafa Ghanizada, Vamsee Mallajosyula, et al. Differential roles of human CD4+ and CD8+ regulatory T cells in controlling self-reactive immune responses. Nature Immunology. 2025:1-10. doi:10.1038/s41590-024-02062-x

Titilola D. Kalejaiye, Rohan Bhattacharya, Samira Musah. A Vascularized Human Organ Chip Reveals SARS-CoV-2 Susceptibility in Developmentally Guided Tissue Maturation. Cellular and Molecular Bioengineering. 2025. doi:10.1007/s12195-025-00851-4

Keitaro Kanie, Takeshi Ito, Genzo Iguchi, et al. Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid. Nature Communications. 2025;16(1):7900. doi:10.1038/s41467-025-63183-x

Angelica Medina, Yu-Chi Chen, Jiajing Zhang, et al. Modeling neurotropic virus infection with functional human neural spheroids as a platform for high-throughput antiviral screening and pathogenesis. Antiviral Research. 2025;242:106248. doi:10.1016/j.antiviral.2025.106248

Yuncheng Man, Ryan R. Posey, Haiqing Bai, et al. Preclinical assessment of pan-influenza A virus CRISPR RNA therapeutics in a human lung alveolus chip. Lab on a Chip. 2025. doi:10.1039/D5LC00156K

Rachel Ringquist, Eshant Bhatia, Paramita Chatterjee, et al. An immune-competent lung-on-a-chip for modelling the human severe influenza infection response. Nature Biomedical Engineering. 2025:1-23. doi:10.1038/s41551-025-01491-9

Jonas Jäger, Maria Thon, Katharina Schimek, Uwe Marx, Susan Gibbs, Jasper J. Koning. Differential biomarker expression of blood and lymphatic vasculature in multi-organ-chips. Scientific Reports. 2025;15(1):14492. doi:10.1038/s41598-025-96367-y

Andrew I. Morrison, Jonas Jäger, Charlotte M. de Winde, et al. Integration of lymphatic vasculature to a human lymph node-on-chip enhances physiological immune properties. Materials Today Bio. 2025;35:102326. doi:10.1016/j.mtbio.2025.102326

S. Tori Ellison, Ian Hayman, Kristy Derr, et al. Limitations of acyclovir and identification of potent HSV antivirals using 3D bioprinted human skin equivalents. Nature Communications. 2025;16(1):9200. doi:10.1038/s41467-025-64245-w