Immune/infectious disease

Nathalia Almeida, Sam Acors, Daniel Cox, et al. Generation and characterization of iPSC models from HIV-1-positive individuals with divergent clinical outcomes. Stem Cell Reports. 2026. doi:10.1016/j.stemcr.2025.102786

Chak Hon Luk, Gabriel L. Conway, Kim Jee Goh, et al. Autologous human iPSC–derived alveolus-on-chip reveals early pathological events of Mycobacterium tuberculosis infection. Science Advances. 2026;12(1):eaea9874. doi:10.1126/sciadv.aea9874

Yansong Peng, Esak Lee. Lymphatics-on-a-chip microphysiological system: engineering lymphatic structure and function in vitro. Lab on a Chip. 2026. doi:10.1039/D5LC00875A

Angelica Medina, Yu-Chi Chen, Jiajing Zhang, et al. Modeling neurotropic virus infection with functional human neural spheroids as a platform for high-throughput antiviral screening and pathogenesis. Antiviral Research. 2025;242:106248. doi:10.1016/j.antiviral.2025.106248

Xin Chen, Mustafa Ghanizada, Vamsee Mallajosyula, et al. Differential roles of human CD4+ and CD8+ regulatory T cells in controlling self-reactive immune responses. Nature Immunology. 2025:1-10. doi:10.1038/s41590-024-02062-x

Titilola D. Kalejaiye, Rohan Bhattacharya, Samira Musah. A Vascularized Human Organ Chip Reveals SARS-CoV-2 Susceptibility in Developmentally Guided Tissue Maturation. Cellular and Molecular Bioengineering. 2025. doi:10.1007/s12195-025-00851-4

Keitaro Kanie, Takeshi Ito, Genzo Iguchi, et al. Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid. Nature Communications. 2025;16(1):7900. doi:10.1038/s41467-025-63183-x

Yuncheng Man, Ryan R. Posey, Haiqing Bai, et al. Preclinical assessment of pan-influenza A virus CRISPR RNA therapeutics in a human lung alveolus chip. Lab on a Chip. 2025. doi:10.1039/D5LC00156K

Rachel Ringquist, Eshant Bhatia, Paramita Chatterjee, et al. An immune-competent lung-on-a-chip for modelling the human severe influenza infection response. Nature Biomedical Engineering. 2025:1-23. doi:10.1038/s41551-025-01491-9

Andrew I. Morrison, Jonas Jäger, Charlotte M. de Winde, et al. Integration of lymphatic vasculature to a human lymph node-on-chip enhances physiological immune properties. Materials Today Bio. 2025;35:102326. doi:10.1016/j.mtbio.2025.102326