00939nas a2200229   4500000000100000000000100001008004100002260001200043653001700055653001700072653002500089100002700114700001800141700002800159700001900187245006500206856005500271300001200326490000600338520035100344022001400695       2021                            d  c2021-0510abiomaterials10aPharmacology10aPreclinical research1 aPartho Protim Adhikary1 aQurrat Ul Ain1 aAndreas Christian Hocke1 aSarah Hedtrich00aCOVID-19 highlights the model dilemma in biomedical research  uhttps://www.nature.com/articles/s41578-021-00305-z  a374-3760 v63 aScientists worldwide struggle to identify suitable animal models to study SARS-CoV-2 infections. Interspecies-related differences, such as host specificity, divergent immune responses, or the unavailability of species-specific reagents hamper the research. Human-based models, such as micro-engineered multi-organs-on-chip, may hold the solution.  a2058-8437