Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

Emily S. Sena, H. Bart van der Worp, Philip M. W. Bath, David W. Howells, Malcolm R. Macleod

PLOS Biology. ;8(3):e1000344. doi: 10.1371/journal.pbio.1000344

Publication bias confounds attempts to use systematic reviews to assess the efficacy of various interventions tested in experiments modelling acute ischaemic stroke, leading to a 30% overstatement of efficacy of interventions tested in animals.

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1000344

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