01092nas a2200301   4500000000100000000000100001008003900002260001700041653001800058653001900076653001800095653002000113653002300133653001700156653002300173653002300196100001800219700002500237700002200262700002100284700002300305245009800328856008200426300001300508490000600521520024900527022001400776       0                             d  cMar 30, 201010aanimal models10aanimal studies10aBibliometrics10aclinical trials10aDatabase searching10aMetaanalysis10aPublication ethics10aSystematic reviews1 aEmily S. Sena1 aH. Bart van der Worp1 aPhilip M. W. Bath1 aDavid W. Howells1 aMalcolm R. Macleod00aPublication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy  uhttps://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1000344  ae10003440 v83 aPublication bias confounds attempts to use systematic reviews to assess the efficacy of various interventions tested in experiments modelling acute ischaemic stroke, leading to a 30% overstatement of efficacy of interventions tested in animals.  a1545-7885