animal models

Helder Constantino, Francesca Pistollato, Troy Seidle. Transitioning biomedical research toward human-centric methodologies: systems-based strategies. Drug Discovery Today. 2024;29(4):103947. doi:10.1016/j.drudis.2024.103947

Thomas Hartung. The (misleading) role of animal models in drug development. Frontiers in Drug Discovery. 2024;4. doi:10.3389/fddsv.2024.1355044

Lina Widerspick, Johanna Friederike Steffen, Dennis Tappe, César Muñoz-Fontela. Animal Model Alternatives in Filovirus and Bornavirus Research. Viruses. 2023;15(1):158. doi:10.3390/v15010158

Carolyn P. Neuhaus. Threats to Benefits: Assessing Knowledge Production in Nonhuman Models of Human Neuropsychiatric Disorders. The Hastings Center Report. 2022;52 Suppl 2(Suppl 2):S34-S40. doi:10.1002/hast.1430

Francesca Pistollato, Camilla Bernasconi, Janine McCarthy, et al. Alzheimer’s Disease, and Breast and Prostate Cancer Research: Translational Failures and the Importance to Monitor Outputs and Impact of Funded Research. Animals (Basel). 2020;10(7):1194. doi:10.3390/ani10071194

Steffi Bressers, Hester van den Elzen, Cathrin Gräwe, Daphne van den Oetelaar, Pieter H. A. Postma, Sybren K. Schoustra. Policy driven changes in animal research practices: mapping researchers’ attitudes towards animal-free innovations using the Netherlands as an example. Research Integrity and Peer Review. 2019;4:8. doi:10.1186/s41073-019-0067-5

Samuel J. Jackson, Helen Prior, Anthony Holmes. The use of human tissue in safety assessment. Journal of Pharmacological and Toxicological Methods. 2018;93:29-34. doi:10.1016/j.vascn.2018.05.003

Emily S. Sena, H. Bart van der Worp, Philip M. W. Bath, David W. Howells, Malcolm R. Macleod. Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy. PLOS Biology. 8(3):e1000344. doi:10.1371/journal.pbio.1000344

H. Bart van der Worp, David W. Howells, Emily S. Sena, et al. Can Animal Models of Disease Reliably Inform Human Studies?. PLOS Medicine. 7(3):e1000245. doi:10.1371/journal.pmed.1000245

Guilherme S. Ferreira, Désirée H. Veening-Griffioen, Wouter P. C. Boon, et al. A standardised framework to identify optimal animal models for efficacy assessment in drug development. PLOS ONE. 14(6):e0218014. doi:10.1371/journal.pone.0218014