Drug Evaluation, Preclinical

Jacintha Shenton, Imein Bousnina, Michael Oropallo, et al. Opportunities and insights from pharmaceutical companies on the current use of new approach methodologies in nonclinical safety assessment. Drug Discovery Today. 2025;30(4):104328. doi:10.1016/j.drudis.2025.104328

Gabriela S. Kronemberger, Fabiana A. Carneiro, Danielle F. Rezende, Leandra S. Baptista. Spheroids and organoids as humanized 3D scaffold-free engineered tissues for SARS-CoV-2 viral infection and drug screening. Artificial Organs. 2021;45(6):548-558. doi:10.1111/aor.13880

Hongbing Wang, Paul C. Brown, Edwin C. Y. Chow, et al. 3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration. Clinical and Translational Science. 2021;14(5):1659-1680. doi:10.1111/cts.13066

Yuling Han, Xiaohua Duan, Liuliu Yang, et al. Identification of SARS-CoV-2 inhibitors using lung and colonic organoids. Nature. 2021;589(7841):270-275. doi:10.1038/s41586-020-2901-9

Julia M. L. Menon, Merel Ritskes-Hoitinga, Pandora Pound, Erica van Oort. The impact of conducting preclinical systematic reviews on researchers and their research: A mixed method case study. PloS One. 2021;16(12):e0260619. doi:10.1371/journal.pone.0260619

Ehsanollah Moradi, Sasan Jalili-Firoozinezhad, Mehran Solati-Hashjin. Microfluidic organ-on-a-chip models of human liver tissue. Acta Biomaterialia. 2020;116:67-83. doi:10.1016/j.actbio.2020.08.041

Else Driehuis, Kai Kretzschmar, Hans Clevers. Establishment of patient-derived cancer organoids for drug-screening applications. Nature Protocols. 2020;15(10):3380-3409. doi:10.1038/s41596-020-0379-4

Uwe Marx, Takafumi Akabane, Tommy B. Andersson, et al. Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development. ALTEX. 2020;37(3):365-394. doi:10.14573/altex.2001241

Michael Balls, Jarrod Bailey, Robert D. Combes. How viable are alternatives to animal testing in determining the toxicities of therapeutic drugs? Expert Opinion on Drug Metabolism & Toxicology. 2019;15(12):985-987. doi:10.1080/17425255.2019.1694662

Elizabeth J. Baker, Nancy A. Beck, Ellen L. Berg, et al. Advancing nonclinical innovation and safety in pharmaceutical testing. Drug Discovery Today. 2019;24(2):624-628. doi:10.1016/j.drudis.2018.11.011