Drug Evaluation, Preclinical

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Elizabeth J. Baker, Nancy A. Beck, Ellen L. Berg, et al. Advancing nonclinical innovation and safety in pharmaceutical testing. Drug Discovery Today. 2019;24(2):624-628. doi:10.1016/j.drudis.2018.11.011
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Pandora Pound, Merel Ritskes-Hoitinga. Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail. Journal of Translational Medicine. 2018;16(1):304. doi:10.1186/s12967-018-1678-1
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Shurong Hou, Hervé Tiriac, Banu Priya Sridharan, et al. Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening. SLAS discovery: advancing life sciences R & D. 2018;23(6):574-584. doi:10.1177/2472555218766842
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William G. Kaelin. Common pitfalls in preclinical cancer target validation. Nature Reviews. Cancer. 2017;17(7):425-440. doi:10.1038/nrc.2017.32
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Jarrod Bailey, Michelle Thew, Michael Balls. Predicting human drug toxicity and safety via animal tests: can any one species predict drug toxicity in any other, and do monkeys help?. Alternatives to laboratory animals: ATLA. 2015;43(6):393-403. doi:10.1177/026119291504300607
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Jarrod Bailey, Michelle Thew, Michael Balls. An analysis of the use of animal models in predicting human toxicology and drug safety. Alternatives to Laboratory Animals. 2014;42(3):181-199. doi:10.1177/026119291404200306
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Valerie C. Henderson, Jonathan Kimmelman, Dean Fergusson, Jeremy M. Grimshaw, Dan G. Hackam. Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments. PLoS Medicine. 2013;10(7):e1001489. doi:10.1371/journal.pmed.1001489
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Victoria E. O’Collins, Malcolm R. Macleod, Geoffrey A. Donnan, Laura L. Horky, Bart H. van der Worp, David W. Howells. 1,026 experimental treatments in acute stroke. Annals of Neurology. 2006;59(3):467-477. doi:10.1002/ana.20741
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