Translation and validation

Fiona Godlee. How predictive and productive is animal research?. BMJ. 2014;348:g3719. doi:10.1136/bmj.g3719

Jarrod Bailey. Monkey-based research on human disease: the implications of genetic differences. Alternatives to Laboratory Animals. 2014;42(5):287-317. doi:10.1177/026119291404200504

Isabella WY Mak, Nathan Evaniew, Michelle Ghert. Lost in translation: animal models and clinical trials in cancer treatment. American Journal of Translational Research. 2014;6(2):114-118. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902221/.

Jennifer A. Hirst, Jeremy Howick, Jeffrey K. Aronson, et al. The need for randomization in animal trials: an overview of systematic reviews. PloS One. 2014;9(6):e98856. doi:10.1371/journal.pone.0098856

Jeffrey L. Cummings, Travis Morstorf, Kate Zhong. Alzheimer’s disease drug-development pipeline: few candidates, frequent failures. Alzheimer’s Research & Therapy. 2014;6:37. doi:10.1186/alzrt269

Michael Hay, David W. Thomas, John L. Craighead, Celia Economides, Jesse Rosenthal. Clinical development success rates for investigational drugs. Nature Biotechnology. 2014;32:40-51. doi:10.1038/nbt.2786

Pandora Pound, Michael B. Bracken. Is animal research sufficiently evidence based to be a cornerstone of biomedical research?. BMJ. 2014;348:g3387. doi:10.1136/bmj.g3387

Marlous Kooijman. Why Animal Studies are Still Being Used in Drug Development. Alternatives to Laboratory Animals. 2013;41(6):79-81. doi:10.1177/026119291304100627

Valerie C. Henderson, Jonathan Kimmelman, Dean Fergusson, Jeremy M. Grimshaw, Dan G. Hackam. Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments. PLoS Medicine. 2013;10(7):e1001489. doi:10.1371/journal.pmed.1001489

Junhee Seok, H. Shaw Warren, Alex G. Cuenca, et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proceedings of the National Academy of Sciences. 2013;110(9):3507-3512. doi:10.1073/pnas.1222878110