Translation and validation

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Vijay Pal Singh, Kunal Pratap, Juhi Sinha, Koundinya Desiraju, Devika Bahal, Ritushree Kukreti. Critical evaluation of challenges and future use of animals in experimentation for biomedical research. International Journal of Immunopathology and Pharmacology. 2016;29(4):551-561. doi:10.1177/0394632016671728

Eleanor Drummond, Thomas Wisniewski. Alzheimer’s disease: experimental models and reality. Acta Neuropathologica. 2016;133(2):155-175. doi:10.1007/s00401-016-1662-x

K. J. Egan, H. M. Vesterinen, V. Beglopoulos, Emily S. Sena, Malcolm R. Macleod. From a mouse: systematic analysis reveals limitations of experiments testing interventions in Alzheimer’s disease mouse models. Evidence-based Preclinical Medicine. 2016;3(1):e00015. doi:10.1002/ebm2.15

Joseph A. DiMasi, Henry G. Grabowski, Ronald W. Hansen. Innovation in the pharmaceutical industry: New estimates of R&D costs. Journal of Health Economics. 2016;47:20-33. doi:10.1016/j.jhealeco.2016.01.012

P Charukeshi Chandrasekera, John J Pippin. The human subject: an integrative animal model for 21st century heart failure research. American Journal of Translational Research. 2015;7(9):1636-1647. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626425/.

Susan Bridgwood Green. Can animal data translate to innovations necessary for a new era of patient-centred and individualised healthcare? Bias in preclinical animal research. BMC Medical Ethics. 2015;16:53. doi:10.1186/s12910-015-0043-7

Aysha Akhtar. The Flaws and Human Harms of Animal Experimentation. Cambridge Quarterly of Healthcare Ethics. 2015;24(4):407-419. doi:10.1017/S0963180115000079

Terry C. Burns, Matthew D. Li, Swapnil Mehta, Ahmed J. Awad, Alexander A. Morgan. Mouse models rarely mimic the transcriptome of human neurodegenerative diseases: A systematic bioinformatics-based critique of preclinical models. European Journal of Pharmacology. 2015;759:101-117. doi:10.1016/j.ejphar.2015.03.021

Jarrod Bailey, Michelle Thew, Michael Balls. An analysis of the use of animal models in predicting human toxicology and drug safety. Alternatives to Laboratory Animals. 2014;42(3):181-199. doi:10.1177/026119291404200306