Translation and validation

Joseph P. Garner. The Significance of Meaning: Why Do Over 90% of Behavioral Neuroscience Results Fail to Translate to Humans, and What Can We Do to Fix It?. ILAR Journal. 2014;55(3):438-456. doi:10.1093/ilar/ilu047

Jeffrey L. Cummings, Travis Morstorf, Kate Zhong. Alzheimer’s disease drug-development pipeline: few candidates, frequent failures. Alzheimer’s Research & Therapy. 2014;6:37. doi:10.1186/alzrt269

Michael Hay, David W. Thomas, John L. Craighead, Celia Economides, Jesse Rosenthal. Clinical development success rates for investigational drugs. Nature Biotechnology. 2014;32:40-51. doi:10.1038/nbt.2786

Pandora Pound, Michael B. Bracken. Is animal research sufficiently evidence based to be a cornerstone of biomedical research?. BMJ. 2014;348:g3387. doi:10.1136/bmj.g3387

Marlous Kooijman. Why Animal Studies are Still Being Used in Drug Development. Alternatives to Laboratory Animals. 2013;41(6):79-81. doi:10.1177/026119291304100627

Valerie C. Henderson, Jonathan Kimmelman, Dean Fergusson, Jeremy M. Grimshaw, Dan G. Hackam. Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments. PLoS Medicine. 2013;10(7):e1001489. doi:10.1371/journal.pmed.1001489

Junhee Seok, H. Shaw Warren, Alex G. Cuenca, et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proceedings of the National Academy of Sciences. 2013;110(9):3507-3512. doi:10.1073/pnas.1222878110

John Pippin. Animal Research in Medical Sciences: Seeking a Convergence of Science, Medicine, and Animal Law. South Texas Law Review. 2012;54:469. https://www.wellbeingintlstudiesrepository.org/acwp_all/14.

Myfanwy Morgan, Christine A. Barry, Jenny L. Donovan, Jane Sandall, Charles D. A. Wolfe, Annette Boaz. Implementing ‘translational’ biomedical research: Convergence and divergence among clinical and basic scientists. Social Science & Medicine. 2011;73(7):945-952. doi:10.1016/j.socscimed.2011.06.060

Matthew M. Davis, Amy T. Butchart, John R. C. Wheeler, Margaret S. Coleman, Dianne C. Singer, Gary L. Freed. Failure-to-success ratios, transition probabilities and phase lengths for prophylactic vaccines versus other pharmaceuticals in the development pipeline. Vaccine. 2011;29(51):9414-9416. doi:10.1016/j.vaccine.2011.09.128