Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases

Konstantinos K. Tsilidis, Orestis A. Panagiotou, Emily S. Sena, Eleni Aretouli, Evangelos Evangelou, David W. Howells, Rustam Al-Shahi Salman, Malcolm R. Macleod, John P. A. Ioannidis
PLOS Biology. ;11(7):e1001609. doi: 10.1371/journal.pbio.1001609

The evaluation of 160 meta-analyses of animal studies on potential treatments for neurological disorders reveals that the number of statistically significant results was too large to be true, suggesting biases.

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001609
Keywords
animal studies
Brain diseases
Brainstem
Cerebral ischemia
Dopamine
Ischemia
Metaanalysis
Neurology
Library Collection(s)
Translation and validation
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