01168nas a2200349   4500000000100000000000100001008003900002260001700041653001900058653001900077653001400096653002200110653001300132653001300145653001700158653001400175100002900189700002600218700001800244700001900262700002400281700002100305700002700326700002300353700002500376245008600401856008200487300001300569490000700582520021500589022001400804       0                             d  cJul 16, 201310aanimal studies10aBrain diseases10aBrainstem10aCerebral ischemia10aDopamine10aIschemia10aMetaanalysis10aNeurology1 aKonstantinos K. Tsilidis1 aOrestis A. Panagiotou1 aEmily S. Sena1 aEleni Aretouli1 aEvangelos Evangelou1 aDavid W. Howells1 aRustam Al-Shahi Salman1 aMalcolm R. Macleod1 aJohn P. A. Ioannidis00aEvaluation of Excess Significance Bias in Animal Studies of Neurological Diseases  uhttps://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001609  ae10016090 v113 aThe evaluation of 160 meta-analyses of animal studies on potential treatments for neurological disorders reveals that the number of statistically significant results was too large to be true, suggesting biases.  a1545-7885