Drug development

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Valentina Paloschi, Maria Sabater-Lleal, Heleen Middelkamp, et al. Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases. Cardiovascular Research. 2021;117(14):2742-2754. doi:10.1093/cvr/cvab088
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Argus M. Sun, Tyler Hoffman, Bao Q. Luu, Nureddin Ashammakhi, Song Li. Application of lung microphysiological systems to COVID-19 modeling and drug discovery: a review. Bio-Design and Manufacturing. 2021;4(4):757-775. doi:10.1007/s42242-021-00136-5
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Uwe Marx, Takafumi Akabane, Tommy B. Andersson, et al. Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development. ALTEX. 2020;37(3):365-394. doi:10.14573/altex.2001241
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David B. Chou, Viktoras Frismantas, Yuka Milton, et al. On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology. Nature Biomedical Engineering. 2020;4(4):394-406. doi:10.1038/s41551-019-0495-z
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S. Vincent Rajkumar. The high cost of prescription drugs: causes and solutions. Blood Cancer Journal. 2020;10(6):71. doi:10.1038/s41408-020-0338-x
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Gail A. Van Norman. Limitations of Animal Studies for Predicting Toxicity in Clinical Trials: Is it Time to Rethink Our Current Approach?. JACC. Basic to translational science. 2019;4(7):845-854. doi:10.1016/j.jacbts.2019.10.008
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Aroon D. Hingorani, Valerie Kuan, Chris Finan, et al. Improving the odds of drug development success through human genomics: modelling study. Scientific Reports. 2019;9(1):18911. doi:10.1038/s41598-019-54849-w
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Désirée H. Veening-Griffioen, Guilherme S. Ferreira, Peter J. K. Van Meer, et al. Are some animal models more equal than others? A case study on the translational value of animal models of efficacy for Alzheimer’s disease. European Journal of Pharmacology. 2019;859:172524. doi:10.1016/j.ejphar.2019.172524
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