Drug development

Aakash Patel, Suruchi Poddar, Daniel Nierenberg, et al. Microphysiological system to address the opioid crisis: A novel multi-organ model of acute opioid overdose and recovery. Current Research in Toxicology. 2025;8:100209. doi:10.1016/j.crtox.2024.100209

Hiroshi Kimura, Masaki Nishikawa, Naokata Kutsuzawa, et al. Advancements in Microphysiological systems: Exploring organoids and organ-on-a-chip technologies in drug development -focus on pharmacokinetics related organs-. Drug Metabolism and Pharmacokinetics. 2025;60:101046. doi:10.1016/j.dmpk.2024.101046

Surat Parvatam, Francesca Pistollato, Lindsay J. Marshall, et al. Human-based complex in vitro models: their promise and potential for rare disease therapeutics. Frontiers in Cell and Developmental Biology. 2025;13. doi:10.3389/fcell.2025.1526306

Catharine E. Krebs, Kathrin Herrmann. Confronting the bias towards animal experimentation (animal methods bias). Frontiers in Drug Discovery. 2024;4. doi:10.3389/fddsv.2024.1347798

Eric Vallabh Minikel, Jeffery L. Painter, Coco Chengliang Dong, Matthew R. Nelson. Refining the impact of genetic evidence on clinical success. Nature. 2024:1-6. doi:10.1038/s41586-024-07316-0

Thomas Hartung. The (misleading) role of animal models in drug development. Frontiers in Drug Discovery. 2024;4. doi:10.3389/fddsv.2024.1355044

Pelin L. Candarlioglu, Louise Delsing, Lauren Gauthier, et al. Application of microphysiological systems for nonclinical evaluation of cell therapies. Alternatives to Animal Experimentation. 2024;41(3):469-484. doi:10.14573/altex.2402201

Ingrid Berg, Pia Härvelid, Wolfgang Emanuel Zürrer, Marianna Rosso, Daniel S. Reich, Benjamin Victor Ineichen. Which experimental factors govern successful animal-to-human translation in multiple sclerosis drug development? A systematic review and meta-analysis. eBioMedicine. 2024;110. doi:10.1016/j.ebiom.2024.105434

Katerina Trajanoska, Claude Bhérer, Daniel Taliun, Sirui Zhou, J. Brent Richards, Vincent Mooser. From target discovery to clinical drug development with human genetics. Nature. 2023;620(7975):737-745. doi:10.1038/s41586-023-06388-8

Julia Y. Co, Jessica A. Klein, Serah Kang, Kimberly A. Homan. Toward Inclusivity in Preclinical Drug Development: A Proposition to Start with Intestinal Organoids. Advanced Biology. 2023;7(12):2200333. doi:10.1002/adbi.202200333