Toxicology

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Susan J. Debad, Jason Aungst, Kelly Carstens, et al. State of the science on assessing developmental neurotoxicity using new approach methods. ALTEX - Alternatives to animal experimentation. 2025;42(1):121-144. doi:10.14573/altex.2410231
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Shivangi Shrimali, Minjun Chen, Dongying Li, Weida Tong. New approach methodologies (NAMs) for drug-induced liver injury (DILI): Where are we now? Drug Discovery Today. 2025;30(9):104452. doi:10.1016/j.drudis.2025.104452
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Xiaozhong Huang, Yun Ting Soong, Jiahao Wang, et al. HIVIL: A human <i>in vitro</i> inflammatory liver model recapitulates immune-associated drug effects with high predictivity. NAM Journal. 2025;1:100032. doi:10.1016/j.namjnl.2025.100032
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Andrew S. Robertson, Nahid Latif, Imein Bousnina, et al. Accelerating adoption of new approach methodologies in regulatory decision making: an industry perspective. Nature Reviews Drug Discovery. 2025. doi:10.1038/d41573-025-00038-6
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Katja Graf, José Martin Murrieta-Coxca, Tobias Vogt, et al. Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women. Frontiers in Pharmacology. 2025;16. doi:10.3389/fphar.2025.1528748
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Monica Piergiovanni, Milena Mennecozzi, Erio Barale-Thomas, et al. Bridging imaging-based in vitro methods from biomedical research to regulatory toxicology. Archives of Toxicology. 2025. doi:10.1007/s00204-024-03922-z
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Eike Cöllen, Kristina Bartmann, Jonathan Blum, et al. Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing. ALTEX - Alternatives to animal experimentation. 2025. doi:10.14573/altex.2501091
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K. Taylor, R. Ram, L. Ewart, et al. Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury. Frontiers in Drug Discovery. 2025;5. doi:10.3389/fddsv.2025.1536756
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Jacintha Shenton, Imein Bousnina, Michael Oropallo, et al. Opportunities and insights from pharmaceutical companies on the current use of new approach methodologies in nonclinical safety assessment. Drug Discovery Today. 2025;30(4):104328. doi:10.1016/j.drudis.2025.104328
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Maria T. Baltazar, Sophie Cable, Richard Cubberley, et al. Making safety decisions for a sunscreen active ingredient using next-generation risk assessment: Benzophenone-4 case study. ALTEX. 2025;42(3):511-530. doi:10.14573/altex.2501201
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