Toxicology

K. Taylor, R. Ram, L. Ewart, et al. Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury. Frontiers in Drug Discovery. 2025;5. doi:10.3389/fddsv.2025.1536756

Eike Cöllen, Kristina Bartmann, Jonathan Blum, et al. Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing. ALTEX - Alternatives to animal experimentation. 2025. doi:10.14573/altex.2501091

Monica Piergiovanni, Milena Mennecozzi, Erio Barale-Thomas, et al. Bridging imaging-based in vitro methods from biomedical research to regulatory toxicology. Archives of Toxicology. 2025. doi:10.1007/s00204-024-03922-z

Katja Graf, José Martin Murrieta-Coxca, Tobias Vogt, et al. Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women. Frontiers in Pharmacology. 2025;16. doi:10.3389/fphar.2025.1528748

Andrew S. Robertson, Nahid Latif, Imein Bousnina, et al. Accelerating adoption of new approach methodologies in regulatory decision making: an industry perspective. Nature Reviews Drug Discovery. 2025. doi:10.1038/d41573-025-00038-6

Noelia Antón-Bolaños, Irene Faravelli, Tyler Faits, et al. Brain Chimeroids reveal individual susceptibility to neurotoxic triggers. Nature. 2024;631(8019):142-149. doi:10.1038/s41586-024-07578-8

Marie Corradi, Thomas Luechtefeld, Alyanne M. de Haan, et al. The application of natural language processing for the extraction of mechanistic information in toxicology. Frontiers in Toxicology. 2024;6. doi:10.3389/ftox.2024.1393662

Veronica Zingales, Maria Rosaria Esposito, Noemi Torriero, Mercedes Taroncher, Elisa Cimetta, María-José Ruiz. The Growing Importance of Three-Dimensional Models and Microphysiological Systems in the Assessment of Mycotoxin Toxicity. Toxins. 2023;15(7):422. doi:10.3390/toxins15070422

Isabel Tamargo-Rubio, Anna Bella Simpson, Joanne A. Hoogerland, Jingyuan Fu. Human induced pluripotent stem cell–derived liver-on-a-chip for studying drug metabolism: the challenge of the cytochrome P450 family. Frontiers in Pharmacology. 2023;14. https://www.frontiersin.org/articles/10.3389/fphar.2023.1223108.

Vivek S Patel, Khalid Amin, Adam Wahab, et al. Cryopreserved human precision-cut lung slices provide an immune competent pulmonary test system for “on-demand” use and long-term cultures. Toxicological Sciences. 2023;191(2):253-265. doi:10.1093/toxsci/kfac136