Gastrointestinal system

Olga Mitrofanova, Mikhail Nikolaev, Quan Xu, et al. Bioengineered human colon organoids with in vivo-like cellular complexity and function. Cell Stem Cell. 2024;31(8):1175-1186.e7. doi:10.1016/j.stem.2024.05.007

Thomas W. Dennison, Rachel D. Edgar, Felicity Payne, et al. Patient-derived organoid biobank identifies epigenetic dysregulation of intestinal epithelial MHC-I as a novel mechanism in severe Crohn’s Disease. Gut. 2024;73:1464-1477. doi:10.1136/gutjnl-2024-332043

Victor Calero, Patrícia M. Rodrigues, Tiago Dias, et al. A miniaturised semi-dynamic in-vitro model of human digestion. Scientific Reports. 2024;14:11923. doi:10.1038/s41598-024-54612-w

Renée Moerkens, Joram Mooiweer, Aarón D. Ramírez-Sánchez, et al. An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal, and neural cells. Cell Reports. 2024;43(7). doi:10.1016/j.celrep.2024.114247

Longjin Zheng, Yang Zhan, Chenxuan Wang, et al. Technological advances and challenges in constructing complex gut organoid systems. Frontiers in Cell and Developmental Biology. 2024;12. doi:10.3389/fcell.2024.1432744

Jianbo Zhang, Yu-Ja Huang, Martin Trapecar, et al. An immune-competent human gut microphysiological system enables inflammation-modulation by Faecalibacterium prausnitzii. npj Biofilms and Microbiomes. 2024;10(1):1-11. doi:10.1038/s41522-024-00501-z

Jiandong Yang, Yoshikazu Hirai, Kei Iida, et al. Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease. Communications Biology. 2023;6(1):1-14. doi:10.1038/s42003-023-04710-8

Changxiu Xian, Jiaxin Zhang, Suqing Zhao, Xiang-Guang Li. Gut-on-a-chip for disease models. Journal of Tissue Engineering. 2023;14:20417314221149882. doi:10.1177/20417314221149882

Wyatt E. Lanik, Cliff J. Luke, Lila S. Nolan, et al. Microfluidic device facilitates in vitro modeling of human neonatal necrotizing enterocolitis–on-a-chip. JCI Insight. 2023;8(8):e146496. doi:10.1172/jci.insight.146496

Sunghee Estelle Park, Shawn Kang, Jungwook Paek, et al. Geometric engineering of organoid culture for enhanced organogenesis in a dish. Nature Methods. 2022;19(11):1449-1460. doi:10.1038/s41592-022-01643-8