Cardiovascular system

Jennifer D. Lee, Ankit Kumar, Tanmay Mathur, Abhishek Jain. Vascular architecture-on-chip: engineering complex blood vessels for reproducing physiological and heterogeneous hemodynamics and endothelial function. Lab on a Chip. 2025;25(11):2620-2631. doi:10.1039/D4LC00968A

Ziteng Huang, Keran Jia, Yadan Tan, et al. Advances in cardiac organoid research: implications for cardiovascular disease treatment. Cardiovascular Diabetology. 2025;24(1):25. doi:10.1186/s12933-025-02598-8

Beiqin Liu, Shuyue Wang, Hong Ma, et al. Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling. Journal of Translational Medicine. 2025;23(1):132. doi:10.1186/s12967-024-05986-y

Cristiane M. Franca, Maria Elisa Lima Verde, Alice Corrêa Silva-Sousa, et al. Perivascular cells function as key mediators of mechanical and structural changes in vascular capillaries. Science Advances. 2025;11(2):eadp3789. doi:10.1126/sciadv.adp3789

M. Iveth Garcia, Keri Dame, Verena Charwat, et al. Human induced pluripotent stem cell-derived cardiomyocytes and their use in a cardiac organ-on-a-chip to assay electrophysiology, calcium and contractility. Nature Protocols. 2025:1-47. doi:10.1038/s41596-025-01166-4

Ana Kojic, Javid Moslehi, Bonnie Ky, Joseph C. Wu. Cardiometabolic disease and cardio-oncology: Insights from iPSC models and tissue engineering. Cell Reports Medicine. 2025;6(9):102261. doi:10.1016/j.xcrm.2025.102261

Chengyi Tu, Arianne Caudal, Yu Liu, Sanjiv M. Narayan, Joseph C. Wu. Modeling heart rhythm using human engineered heart tissues. Nature Protocols. 2025:1-24. doi:10.1038/s41596-025-01217-w

Colin O’Hern, Sammantha Caywood, Shakhlo Aminova, et al. Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling. Cell Stem Cell. 2025;32(11):1671-1690.e13. doi:10.1016/j.stem.2025.09.011

Rohan Bhattacharya, Tarsha Ward, Titilola D. Kalejaiye, et al. Engineered human induced pluripotent stem cell models reveal altered podocytogenesis in congenital heart disease-associated SMAD2 mutations. Nature Biomedical Engineering. 2025:1-20. doi:10.1038/s41551-025-01543-0

Vi Nguyen, Anna Harper, Mackenzie Azuero, et al. Vascular Organoids Derived from Capillary malformation-induced Pluripotent Stem Cells Exhibit Disease-Relevant Phenotypes. Stem Cell Reviews and Reports. 2025. doi:10.1007/s12015-025-10984-8