Experimental models of disease

Mattia Francesco Maria Gerli, Giuseppe Calà, Max Arran Beesley, et al. Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids. Nature Medicine. 2024:1-13. doi:10.1038/s41591-024-02807-z

Min Jae Song, Russ Quinn, Eric Nguyen, et al. Bioprinted 3D outer retina barrier uncovers RPE-dependent choroidal phenotype in advanced macular degeneration. Nature Methods. 2023;20(1):149-161. doi:10.1038/s41592-022-01701-1

Robert Phillips. Progress toward ‘bone-on-a-chip’. Nature Reviews Rheumatology. 2023:1-1. doi:10.1038/s41584-023-00998-2

Daniel Reumann, Christian Krauditsch, Maria Novatchkova, et al. In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain–striatum–cortex assembloids. Nature Methods. 2023;20:2034-2047. doi:10.1038/s41592-023-02080-x

Jack W. Scannell, James Bosley, John A. Hickman, et al. Predictive validity in drug discovery: what it is, why it matters and how to improve it. Nature Reviews Drug Discovery. 2022;21(12):915-931. doi:10.1038/s41573-022-00552-x

Larry Carbone. Estimating mouse and rat use in American laboratories by extrapolation from Animal Welfare Act-regulated species. Scientific Reports. 2021;11(1):493. doi:10.1038/s41598-020-79961-0

David B. Chou, Viktoras Frismantas, Yuka Milton, et al. On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology. Nature Biomedical Engineering. 2020;4(4):394-406. doi:10.1038/s41551-019-0495-z

Onur Kilic, Arum Yoon, Sagar R. Shah, et al. A microphysiological model of the bronchial airways reveals the interplay of mechanical and biochemical signals in bronchospasm. Nature Biomedical Engineering. 2019;3:532-544. doi:10.1038/s41551-019-0366-7