Drug screening

Bettina Lickiss, Jan Hunker, Jamie Bhagwan, et al. Chamber-specific contractile responses of atrial and ventricular hiPSC-cardiomyocytes to GPCR and ion channel targeting compounds: A microphysiological system for cardiac drug development. Journal of Pharmacological and Toxicological Methods. 2024;128:107529. doi:10.1016/j.vascn.2024.107529

Souradeep Dey, Amritha Bhat, G. Janani, Vartik Shandilya, Raghvendra Gupta, Biman B. Mandal. Microfluidic human physiomimetic liver model as a screening platform for drug induced liver injury. Biomaterials. 2024;310:122627. doi:10.1016/j.biomaterials.2024.122627

Zhen Fang, Peijuan Li, Fengying Du, Liang Shang, Leping Li. The role of organoids in cancer research. Experimental Hematology & Oncology. 2023;12(1):69. doi:10.1186/s40164-023-00433-y

Longlong Si, Haiqing Bai, Melissa Rodas, et al. A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics. Nature Biomedical Engineering. 2021;5(8):815-829. doi:10.1038/s41551-021-00718-9

Hubert Dirven, Gunn E. Vist, Sricharan Bandhakavi, et al. Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review. Scientific Reports. 2021;11(1):6403. doi:10.1038/s41598-021-85708-2

Gabriela S. Kronemberger, Fabiana A. Carneiro, Danielle F. Rezende, Leandra S. Baptista. Spheroids and organoids as humanized 3D scaffold-free engineered tissues for SARS-CoV-2 viral infection and drug screening. Artificial Organs. 2021;45(6):548-558. doi:10.1111/aor.13880

Ehsanollah Moradi, Sasan Jalili-Firoozinezhad, Mehran Solati-Hashjin. Microfluidic organ-on-a-chip models of human liver tissue. Acta Biomaterialia. 2020;116:67-83. doi:10.1016/j.actbio.2020.08.041

Zhengyu Zou, Zhun Lin, Chenglin Wu, et al. Micro-Engineered Organoid-on-a-Chip Based on Mesenchymal Stromal Cells to Predict Immunotherapy Responses of HCC Patients. Advanced Science. n/a(n/a):2302640. doi:10.1002/advs.202302640