Translation and validation

Nora Franzen, Wim H. van Harten, Valesca P. Retèl, Peter Loskill, Janny van den Eijnden-van Raaij, Maarten IJzerman. Impact of organ-on-a-chip technology on pharmaceutical R&D costs. Drug Discovery Today. 2019;24(9):1720-1724. doi:10.1016/j.drudis.2019.06.003

Gail A. Van Norman. Limitations of Animal Studies for Predicting Toxicity in Clinical Trials: Is it Time to Rethink Our Current Approach?. JACC. Basic to translational science. 2019;4(7):845-854. doi:10.1016/j.jacbts.2019.10.008

John J. Pippin, Sarah E. Cavanaugh, Francesca Pistollato. Animal Research for Alzheimer Disease: Failures of Science and Ethics. In: Kathrin Herrmann, Kimberley Jayne, eds. Animal Experimentation: Working Towards a Paradigm Change. Brill; 2019:480-516. https://www.jstor.org/stable/10.1163/j.ctvjhzq0f.27.

John P. Gluck. Afterword: Evidence over Interests. In: Kathrin Herrmann, Kimberley Jayne, eds. Animal Experimentation. Brill; 2019:689-691. https://www.jstor.org/stable/10.1163/j.ctvjhzq0f.36.

Kathrin Herrmann, Kimberley Jayne, eds. Animal Experimentation: Working Towards a Paradigm Change. Brill; 2019. https://www.jstor.org/stable/10.1163/j.ctvjhzq0f.

Jarrod Bailey, Michael Balls. Recent efforts to elucidate the scientific validity of animal-based drug tests by the pharmaceutical industry, pro-testing lobby groups, and animal welfare organisations. BMC Medical Ethics. 2019;20(1):16. doi:10.1186/s12910-019-0352-3

Kathrin Herrmann, Francesca Pistollato, Martin L. Stephens. Beyond the 3Rs: Expanding the use of human-relevant replacement methods in biomedical research. Alternatives to Animal Experimentation. 2019;36(3):343-352. doi:10.14573/altex.1907031

Cathalijn H. C. Leenaars, Carien Kouwenaar, Frans R. Stafleu, et al. Animal to human translation: a systematic scoping review of reported concordance rates. Journal of Translational Medicine. 2019;17(1):223. doi:10.1186/s12967-019-1976-2

Désirée H. Veening-Griffioen, Guilherme S. Ferreira, Peter J. K. Van Meer, et al. Are some animal models more equal than others? A case study on the translational value of animal models of efficacy for Alzheimer’s disease. European Journal of Pharmacology. 2019;859:172524. doi:10.1016/j.ejphar.2019.172524

Chi Heem Wong, Kien Wei Siah, Andrew W Lo. Estimation of clinical trial success rates and related parameters. Biostatistics. 2019;20(2):273-286. doi:10.1093/biostatistics/kxx069