Reviews and perspectives

Zehra Yildirim, Kyle Swanson, Xuekun Wu, James Zou, Joseph Wu. Next-Gen Therapeutics: Pioneering Drug Discovery with iPSCs, Genomics, AI, and Clinical Trials in a Dish. Annual Review of Pharmacology and Toxicology. 2025;65(Volume 65, 2025):71-90. doi:10.1146/annurev-pharmtox-022724-095035

Tina Woods, Nic Palmarini, Lynne Corner, et al. Cities, communities and clinics can be testbeds for human exposome and aging research. Nature Medicine. 2025:1-3. doi:10.1038/s41591-025-03519-8

AM Anu Varshini, Usha Nandini S, V Ramesh Kumar, Thangam T, Krupakar Parthasarathy. New frontiers in anti-cancer drug testing: The need for a relevant In vitro testing model. NAM Journal. 2025;1:100003. doi:10.1016/j.namjnl.2024.100003

Hiroshi Kimura, Masaki Nishikawa, Naokata Kutsuzawa, et al. Advancements in Microphysiological systems: Exploring organoids and organ-on-a-chip technologies in drug development -focus on pharmacokinetics related organs-. Drug Metabolism and Pharmacokinetics. 2025;60:101046. doi:10.1016/j.dmpk.2024.101046

Surat Parvatam, Francesca Pistollato, Lindsay J. Marshall, et al. Human-based complex in vitro models: their promise and potential for rare disease therapeutics. Frontiers in Cell and Developmental Biology. 2025;13. doi:10.3389/fcell.2025.1526306

Monique M. A. Verstegen, Rob P. Coppes, Anne Beghin, et al. Clinical applications of human organoids. Nature Medicine. 2025:1-13. doi:10.1038/s41591-024-03489-3

Lena Smirnova, Thomas Hartung. The Promise and Potential of Brain Organoids. Advanced Healthcare Materials. 2024:2302745. doi:10.1002/adhm.202302745

Jonas Cerneckis, Hongxia Cai, Yanhong Shi. Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications. Signal Transduction and Targeted Therapy. 2024;9(1):1-26. doi:10.1038/s41392-024-01809-0

Darwin R. Reyes, Mandy B. Esch, Lorna Ewart, et al. From animal testing to in vitro systems: advancing standardization in microphysiological systems. Lab on a Chip. 2024. doi:10.1039/D3LC00994G

Surat Parvatam, David Pamies, Francesca Pistollato, et al. Taking the leap toward human-specific nonanimal methodologies: The need for harmonizing global policies for microphysiological systems. Stem Cell Reports. 2024;19(1):37-40. doi:10.1016/j.stemcr.2023.11.008