Nervous system

Etta Carricaburu, Orion Benner, Scott R. Burlingham, et al. Gephyrin promotes autonomous assembly and synaptic localization of GABAergic postsynaptic components without presynaptic GABA release. Proceedings of the National Academy of Sciences. 2024;121(26):e2315100121. doi:10.1073/pnas.2315100121

Mohammed R. Shaker, Andrii Slonchak, Bahaa Al-mhanawi, et al. Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2. Science Advances. 2024;10(23):eadj4735. doi:10.1126/sciadv.adj4735

Eric Courchesne, Vani Taluja, Sanaz Nazari, et al. Embryonic origin of two ASD subtypes of social symptom severity: the larger the brain cortical organoid size, the more severe the social symptoms. Molecular Autism. 2024;15(1):22. doi:10.1186/s13229-024-00602-8

Catarina Martins-Costa, Andrea Wiegers, Vincent A. Pham, et al. ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum. Cell Stem Cell. 2024;31(6):866-885.e14. doi:10.1016/j.stem.2024.04.014

Alexander Shapson-Coe, Michał Januszewski, Daniel R. Berger, et al. A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution. Science. 2024;384(6696):eadk4858. doi:10.1126/science.adk4858

Rodi Kado Abdalkader, Romanas Chaleckis, Takuya Fujita, Ken-ichiro Kamei. Modeling dry eye with an air–liquid interface in corneal epithelium-on-a-chip. Scientific Reports. 2024;14:4185. doi:10.1038/s41598-024-54736-z

Yi Liu, Rachna Balaji, Marcelo A. Szymanski de Toledo, et al. The pain target NaV1.7 is expressed late during human iPS cell differentiation into sensory neurons as determined in high-resolution imaging. Pflügers Archiv - European Journal of Physiology. 2024;476:975-992. doi:10.1007/s00424-024-02945-w

Xufeng Xue, Yung Su Kim, Alfredo-Isaac Ponce-Arias, et al. A patterned human neural tube model using microfluidic gradients. Nature. 2024;628:391-399. doi:10.1038/s41586-024-07204-7

Dorit Trudler, Swagata Ghatak, Michael Bula, et al. Dysregulation of miRNA expression and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids. Molecular Psychiatry. 2024:1-18. doi:10.1038/s41380-024-02761-9

Marcella Birtele, Madeline Lancaster, Giorgia Quadrato. Modelling human brain development and disease with organoids. Nature Reviews Molecular Cell Biology. 2024:1-24. doi:10.1038/s41580-024-00804-1