Nervous system

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Manasi Agrawal, Meghal Desai, Shruti Ghumra, Yashashree Bhorkar, Pabitra K. Sahoo. Human induced pluripotent stem cell-based models for studying neural repair. Progress in Neurobiology. 2026;260:102907. doi:10.1016/j.pneurobio.2026.102907
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Julien Klimmt, Carolina Cardoso Gonçalves, Jessica Valentina Montgomery, et al. A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes. Nature Neuroscience. 2026:1-17. doi:10.1038/s41593-026-02367-0
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Benedetta Frizzi, Adriana Margarida Barbosa Correia, Irene Faravelli, Ludo Van Den Bosch, Stefania Corti. Using human 3D organoid models to gain mechanistic insight in motor neuron diseases. Nature Reviews Neuroscience. 2026:1-21. doi:10.1038/s41583-026-01057-x
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Vukasin M. Jovanovic, Narisu Narisu, Lori L. Bonnycastle, et al. Scalable hypothalamic neuron differentiation from human pluripotent stem cells suitable for modeling metabolic disorders. Stem Cell Reports. 2026. doi:10.1016/j.stemcr.2026.102958
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George M. Gibbons, Tanja Fuchsberger, Mai Abdelgawad, et al. A human corticospinal organoid-slice connectoid model informs enhancer strategies for post-injury axon regrowth. Cell Reports. 2026;45(6). doi:10.1016/j.celrep.2026.117399
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Seungmi Ryu, Jason Inman, Hyenjong Hong, et al. Modeling Friedreich’s ataxia with Bergmann glia-enriched human cerebellar organoids. Communications Biology. 2026. doi:10.1038/s42003-026-10180-5
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Tatsuya Osaki, Chloe Delepine, Yuma Osako, et al. Early differential impact of MeCP2 mutations on functional networks in Rett syndrome patient-derived human cortical organoids. Nature Communications. 2026. doi:10.1038/s41467-026-71458-0
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Miguel F. Tenreiro, Alysson R. Muotri. Reconstructing human corticogenesis: Insights from cerebral organoids into neurodevelopment and disease modeling. Developmental Cell. 2026:S1534-5807(26)00083. doi:10.1016/j.devcel.2026.02.018
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Barbara Pavan, Giada Botti, Alessandro Dalpiaz, Raffaello Sbordoni, Abdullah Talari, Valon Llabjani. A new microphysiological platform to study the permeation of neuroactive agents across intestinal and brain barriers. Biofabrication. 2026;18(2):025013. doi:10.1088/1758-5090/ae514c
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Matthew Price, Francesca Pistollato. Beyond the amyloid hypothesis: leveraging human-centered complex in vitro models to decode Alzheimer’s disease etiology. Frontiers in Toxicology. 2026;7. doi:10.3389/ftox.2025.1753572
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