Immune/infectious disease

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Min Zhang, Peng Wang, Ronghua Luo, et al. Biomimetic Human Disease Model of SARS-CoV-2-Induced Lung Injury and Immune Responses on Organ Chip System. Advanced Science. 2021;8(3):2002928. doi:10.1002/advs.202002928
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Partho Protim Adhikary, Qurrat Ul Ain, Andreas Christian Hocke, Sarah Hedtrich. COVID-19 highlights the model dilemma in biomedical research. Nature Reviews Materials. 2021;6(5):374-376. doi:10.1038/s41578-021-00305-z
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Vivek V. Thacker, Kunal Sharma, Neeraj Dhar, Gian-Filippo Mancini, Jessica Sordet-Dessimoz, John D. McKinney. Rapid endotheliitis and vascular damage characterize SARS-CoV-2 infection in a human lung-on-chip model. EMBO reports. 2021;22(6):e52744. doi:10.15252/embr.202152744
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Longlong Si, Haiqing Bai, Crystal Yuri Oh, Lei Jin, Rachelle Prantil-Baun, Donald E. Ingber. Clinically Relevant Influenza Virus Evolution Reconstituted in a Human Lung Airway-on-a-Chip. Heba H. Mostafa, ed. Microbiology Spectrum. 2021;9(2):e00257-21. doi:10.1128/Spectrum.00257-21
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Smriti Mallapaty. The mini lungs and other organoids helping to beat COVID. Nature. 2021;593(7860):492-494. doi:10.1038/d41586-021-01395-z
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A. L. Gard, R. J. Luu, C. R. Miller, et al. High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro. Scientific Reports. 2021;11(1):14961. doi:10.1038/s41598-021-94095-7
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Jelte van der Vaart, Mart M. Lamers, Bart L. Haagmans, Hans Clevers. Advancing lung organoids for COVID-19 research. Disease Models & Mechanisms. 2021;14(6):dmm049060. doi:10.1242/dmm.049060
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Yuling Han, Xiaohua Duan, Liuliu Yang, et al. Identification of SARS-CoV-2 inhibitors using lung and colonic organoids. Nature. 2021;589(7841):270-275. doi:10.1038/s41586-020-2901-9
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Longlong Si, Haiqing Bai, Melissa Rodas, et al. A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics. Nature Biomedical Engineering. 2021;5(8):815-829. doi:10.1038/s41551-021-00718-9
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Alice Maria Giani, Shuibing Chen. Human pluripotent stem cell-based organoids and cell platforms for modelling SARS-CoV-2 infection and drug discovery. Stem Cell Research. 2021;53:102207. doi:10.1016/j.scr.2021.102207
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