Aging

Seungman Park, Thomas C. Laskow, Jingchun Chen, Prasun Guha, Buddhadeb Dawn, Deok-Ho Kim. Microphysiological systems for human aging research. Aging Cell. 2024;23(3):e14070. doi:10.1111/acel.14070

Abhijeet Venkataraman, Ivan Kordic, JiaXun Li, et al. Decoding senescence of aging single cells at the nexus of biomaterials, microfluidics, and spatial omics. npj Aging. 2024;10(1):1-27. doi:10.1038/s41514-024-00178-w

Patricia R. Pitrez, Luis M. Monteiro, Oliver Borgogno, Xavier Nissan, Jerome Mertens, Lino Ferreira. Cellular reprogramming as a tool to model human aging in a dish. Nature Communications. 2024;15(1):1816. doi:10.1038/s41467-024-46004-5

Leandro H. Gallo, Nesar Akanda, Kaveena Autar, et al. A functional aged human iPSC-cortical neuron model recapitulates Alzheimer’s disease, senescence, and the response to therapeutics. Alzheimer’s & Dementia. 2024;20(9):5940-5960. doi:10.1002/alz.14044

Hyo Lee, Aimee J. Aylward, Richard V. Pearse, et al. Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1. Cell Reports. 2023;42(8):112994. doi:10.1016/j.celrep.2023.112994

Jonas Cerneckis, Guojun Bu, Yanhong Shi. Pushing the boundaries of brain organoids to study Alzheimer’s disease. Trends in Molecular Medicine. 2023;29(8):659-672. doi:10.1016/j.molmed.2023.05.007

Francesca Veronesi, Deyanira Contartese, Laura Di Sarno, Veronica Borsari, Milena Fini, Gianluca Giavaresi. In Vitro Models of Cell Senescence: A Systematic Review on Musculoskeletal Tissues and Cells. International Journal of Molecular Sciences. 2023;24(21):15617. doi:10.3390/ijms242115617

Christiane Hartmann, Luise Herling, Alexander Hartmann, et al. Systematic estimation of biological age of in vitro cell culture systems by an age-associated marker panel. Frontiers in Aging. 2023;4. doi:10.3389/fragi.2023.1129107

Eunkyung Clare Ko, Sarah Spitz, Francesca Michela Pramotton, et al. Accelerating the in vitro emulation of Alzheimer’s disease-associated phenotypes using a novel 3D blood-brain barrier neurosphere co-culture model. Frontiers in Bioengineering and Biotechnology. 2023;11. doi:10.3389/fbioe.2023.1251195

Xianwei Chen, Guoqiang Sun, E Tian, et al. Modeling Sporadic Alzheimer’s Disease in Human Brain Organoids under Serum Exposure. Advanced Science. 2021;8(18):2101462. doi:10.1002/advs.202101462