%0 Journal Article %K DILI %K animal testing %K in vitro methods %K liver injury %K microphysiological systems %K replacement %K safety testing %K spheroids %B Frontiers in Drug Discovery %D 2025 %G English %R 10.3389/fddsv.2025.1536756 %T Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury %U https://www.frontiersin.org/journals/drug-discovery/articles/10.3389/fddsv.2025.1536756/full %V 5 %8 2025-02-19 %! Perspective