%0 Journal Article
%K Artifacts
%K Automation
%K Consanguinity
%K Exons
%K Gain of Function Mutation
%K Gene Frequency
%K Gene Knockdown Techniques
%K Genes, Essential
%K Heterozygote
%K Homozygote
%K Humans
%K Huntingtin Protein
%K Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
%K Loss of Function Mutation
%K Molecular Targeted Therapy
%K Neurodegenerative Diseases
%K Prion Proteins
%K Reproducibility of Results
%K Sample Size
%K tau Proteins
%B Nature
%D 2020
%G eng
%N 7809
%P 459-464
%R 10.1038/s41586-020-2267-z
%T Evaluating drug targets through human loss-of-function genetic variation
%V 581
%8 2020-05