%0 Journal Article %K animal experimentation %K Animals %K Drug Evaluation, Preclinical %K Guidelines as Topic %K Humans %K Research Design %B PLoS Medicine %D 2013 %G eng %N 7 %P e1001489 %R 10.1371/journal.pmed.1001489 %T Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments %U https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001489 %V 10 %8 2013 %! Threats to validity in the design and conduct of preclinical efficacy studies