%0 Journal Article %K animal experimentation %K Animals %K Biomedical Research %K Humans %K Models, Animal %K Research Design %K ethics %K humane endpoints %K Meta-analysis %K pre-clinical trials %K statistics %K Systematic review %K Three Rs %B International Journal of Immunopathology and Pharmacology %D 2016 %G eng %N 4 %P 551-561 %R 10.1177/0394632016671728 %T Critical evaluation of challenges and future use of animals in experimentation for biomedical research %V 29 %8 2016-12