TY - JOUR
KW - Animals
KW - Communicable Diseases
KW - Humans
KW - Models, Biological
KW - Tissue engineering
AU - Melody Mills
AU - Mary K. Estes
AB - Limitations of animal infection models have engendered longstanding obstacles in basic science and translational research. Lack of suitable animal models, the need for better predictors of human immune responses and pathogens that grow poorly or not at all outside the human host impact our ability to study infectious agents that cause human disease, generation of essential tools for genetic manipulation of microbial pathogens and development of vaccines, therapeutics and host-targeted immunotherapies. The advent of conceptual and methodological advances in tissue engineering along with collaborative efforts between the bioengineering and infectious diseases scientific communities hold great promise to overcome these significant barriers.
BT - Drug Discovery Today
DA - 2016-09
DO - 10.1016/j.drudis.2016.06.020
IS - 9
LA - eng
N2 - Limitations of animal infection models have engendered longstanding obstacles in basic science and translational research. Lack of suitable animal models, the need for better predictors of human immune responses and pathogens that grow poorly or not at all outside the human host impact our ability to study infectious agents that cause human disease, generation of essential tools for genetic manipulation of microbial pathogens and development of vaccines, therapeutics and host-targeted immunotherapies. The advent of conceptual and methodological advances in tissue engineering along with collaborative efforts between the bioengineering and infectious diseases scientific communities hold great promise to overcome these significant barriers.
PY - 2016
SP - 1540
EP - 1552
T2 - Drug Discovery Today
TI - Physiologically relevant human tissue models for infectious diseases
VL - 21
SN - 1878-5832
ER -