TY - JOUR
KW - Animal Testing Alternatives
KW - Animals
KW - Biomedical Engineering
KW - Cell Culture Techniques
KW - Cells, Cultured
KW - Computer Simulation
KW - Drug Discovery
KW - Humans
KW - Microchip Analytical Procedures
AU - Lucie A. Low
AU - Christine Mummery
AU - Brian R. Berridge
AU - Christopher P. Austin
AU - Danilo A. Tagle
AB - Organs-on-chips (OoCs), also known as microphysiological systems or 'tissue chips' (the terms are synonymous), have attracted substantial interest in recent years owing to their potential to be informative at multiple stages of the drug discovery and development process. These innovative devices could provide insights into normal human organ function and disease pathophysiology, as well as more accurately predict the safety and efficacy of investigational drugs in humans. Therefore, they are likely to become useful additions to traditional preclinical cell culture methods and in vivo animal studies in the near term, and in some cases replacements for them in the longer term. In the past decade, the OoC field has seen dramatic advances in the sophistication of biology and engineering, in the demonstration of physiological relevance and in the range of applications. These advances have also revealed new challenges and opportunities, and expertise from multiple biomedical and engineering fields will be needed to fully realize the promise of OoCs for fundamental and translational applications. This Review provides a snapshot of this fast-evolving technology, discusses current applications and caveats for their implementation, and offers suggestions for directions in the next decade.
BT - Nature Reviews. Drug Discovery
DA - 2021-05
DO - 10.1038/s41573-020-0079-3
IS - 5
LA - eng
N2 - Organs-on-chips (OoCs), also known as microphysiological systems or 'tissue chips' (the terms are synonymous), have attracted substantial interest in recent years owing to their potential to be informative at multiple stages of the drug discovery and development process. These innovative devices could provide insights into normal human organ function and disease pathophysiology, as well as more accurately predict the safety and efficacy of investigational drugs in humans. Therefore, they are likely to become useful additions to traditional preclinical cell culture methods and in vivo animal studies in the near term, and in some cases replacements for them in the longer term. In the past decade, the OoC field has seen dramatic advances in the sophistication of biology and engineering, in the demonstration of physiological relevance and in the range of applications. These advances have also revealed new challenges and opportunities, and expertise from multiple biomedical and engineering fields will be needed to fully realize the promise of OoCs for fundamental and translational applications. This Review provides a snapshot of this fast-evolving technology, discusses current applications and caveats for their implementation, and offers suggestions for directions in the next decade.
PY - 2021
SP - 345
EP - 361
ST - Organs-on-chips
T2 - Nature Reviews. Drug Discovery
TI - Organs-on-chips: into the next decade
UR - https://www.nature.com/articles/s41573-020-0079-3
VL - 20
SN - 1474-1784
ER -