TY - JOUR
KW - body-on-a-chip
KW - microfluidics
KW - microphysiological systems
KW - organ-on-a-chip
KW - tissue chips
KW - tissue-on-a-chip
AU - Leslie Donoghue
AU - Khanh T. Nguyen
AU - Caleb Graham
AU - Palaniappan Sethu
AB - Tissue chips (TCs) and microphysiological systems (MPSs) that incorporate human cells are novel platforms to model disease and screen drugs and provide an alternative to traditional animal studies. This review highlights the basic definitions of TCs and MPSs, examines four major organs/tissues, identifies critical parameters for organization and function (tissue organization, blood flow, and physical stresses), reviews current microfluidic approaches to recreate tissues, and discusses current shortcomings and future directions for the development and application of these technologies. The organs emphasized are those involved in the metabolism or excretion of drugs (hepatic and renal systems) and organs sensitive to drug toxicity (cardiovascular system). This article examines the microfluidic/microfabrication approaches for each organ individually and identifies specific examples of TCs. This review will provide an excellent starting point for understanding, designing, and constructing novel TCs for possible integration within MPS.
BT - Micromachines
DA - 2021/2
DO - 10.3390/mi12020139
IS - 2
LA - en
N2 - Tissue chips (TCs) and microphysiological systems (MPSs) that incorporate human cells are novel platforms to model disease and screen drugs and provide an alternative to traditional animal studies. This review highlights the basic definitions of TCs and MPSs, examines four major organs/tissues, identifies critical parameters for organization and function (tissue organization, blood flow, and physical stresses), reviews current microfluidic approaches to recreate tissues, and discusses current shortcomings and future directions for the development and application of these technologies. The organs emphasized are those involved in the metabolism or excretion of drugs (hepatic and renal systems) and organs sensitive to drug toxicity (cardiovascular system). This article examines the microfluidic/microfabrication approaches for each organ individually and identifies specific examples of TCs. This review will provide an excellent starting point for understanding, designing, and constructing novel TCs for possible integration within MPS.
PY - 2021
EP - 139
T2 - Micromachines
TI - Tissue Chips and Microphysiological Systems for Disease Modeling and Drug Testing
UR - https://www.mdpi.com/2072-666X/12/2/139
VL - 12
Y2 - 2022-12-01
SN - 2072-666X
ER -