TY - JOUR
KW - 3Rs
KW - Acute systemic toxicity
KW - Alternatives
KW - Dermal
KW - Inhalation
KW - LD
KW - Oral
AU - Jon Hamm
AU - Kristie Sullivan
AU - Amy J. Clippinger
AU - Judy Strickland
AU - Shannon Bell
AU - Barun Bhhatarai
AU - Bas Blaauboer
AU - Warren Casey
AU - David Dorman
AU - Anna Forsby
AU - Natàlia Garcia-Reyero
AU - Sean Gehen
AU - Rabea Graepel
AU - Jon Hotchkiss
AU - Anna Lowit
AU - Joanna Matheson
AU - Elissa Reaves
AU - Louis Scarano
AU - Catherine Sprankle
AU - Jay Tunkel
AU - Dan Wilson
AU - Menghang Xia
AU - Hao Zhu
AU - David Allen
AB - Acute systemic toxicity testing provides the basis for hazard labeling and risk management of chemicals. A number of international efforts have been directed at identifying non-animal alternatives for in vivo acute systemic toxicity tests. A September 2015 workshop, Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing, reviewed the state-of-the-science of non-animal alternatives for this testing and explored ways to facilitate implementation of alternatives. Workshop attendees included representatives from international regulatory agencies, academia, nongovernmental organizations, and industry. Resources identified as necessary for meaningful progress in implementing alternatives included compiling and making available high-quality reference data, training on use and interpretation of in vitro and in silico approaches, and global harmonization of testing requirements. Attendees particularly noted the need to characterize variability in reference data to evaluate new approaches. They also noted the importance of understanding the mechanisms of acute toxicity, which could be facilitated by the development of adverse outcome pathways. Workshop breakout groups explored different approaches to reducing or replacing animal use for acute toxicity testing, with each group crafting a roadmap and strategy to accomplish near-term progress. The workshop steering committee has organized efforts to implement the recommendations of the workshop participants.
BT - Toxicology in Vitro
DA - 2017-06-01
DO - 10.1016/j.tiv.2017.01.004
LA - en
N2 - Acute systemic toxicity testing provides the basis for hazard labeling and risk management of chemicals. A number of international efforts have been directed at identifying non-animal alternatives for in vivo acute systemic toxicity tests. A September 2015 workshop, Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing, reviewed the state-of-the-science of non-animal alternatives for this testing and explored ways to facilitate implementation of alternatives. Workshop attendees included representatives from international regulatory agencies, academia, nongovernmental organizations, and industry. Resources identified as necessary for meaningful progress in implementing alternatives included compiling and making available high-quality reference data, training on use and interpretation of in vitro and in silico approaches, and global harmonization of testing requirements. Attendees particularly noted the need to characterize variability in reference data to evaluate new approaches. They also noted the importance of understanding the mechanisms of acute toxicity, which could be facilitated by the development of adverse outcome pathways. Workshop breakout groups explored different approaches to reducing or replacing animal use for acute toxicity testing, with each group crafting a roadmap and strategy to accomplish near-term progress. The workshop steering committee has organized efforts to implement the recommendations of the workshop participants.
PY - 2017
SP - 245
EP - 259
ST - Alternative approaches for identifying acute systemic toxicity
T2 - Toxicology in Vitro
TI - Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing
UR - https://www.sciencedirect.com/science/article/pii/S0887233317300048
VL - 41
Y2 - 2022-09-15
SN - 0887-2333
ER -