TY - JOUR
KW - Cardiovascular Diseases
KW - drug testing
KW - Heart-on-a-chip
KW - In vitro modeling
KW - On-chip detection
AU - Beiqin Liu
AU - Shuyue Wang
AU - Hong Ma
AU - Yulin Deng
AU - Jichen Du
AU - Yimeng Zhao
AU - Yu Chen
AB - Heart-on-a-chip (HoC) devices have emerged as a powerful tool for studying the human heart's intricate functions and dysfunctions in vitro. Traditional preclinical models, such as 2D cell cultures model and animal model, have limitations in accurately predicting human response to cardiovascular diseases and treatments. The HoC approach addresses these shortcomings by recapitulating the microscale anatomy, physiology, and biomechanics of the heart, thereby providing a more clinically relevant platform for drug testing, disease modeling, and personalized therapy. Recent years have seen significant strides in HoC technology, driven by advancements in biomaterials, bioelectronics, and tissue engineering. Here, we first review the construction and on-chip detection in HoC. Then we introduce the current proceedings of in vitro models for studying cardiovascular diseases (CVD) based on the HoC platform, including ischemia and myocardial infarction, cardiac fibrosis, cardiac scar, myocardial hypertrophy and other CVD models. Finally, we discuss the future directions of HoC and related emerging technologies.
BT - Journal of Translational Medicine
DA - 2025-01-30
DO - 10.1186/s12967-024-05986-y
IS - 1
N2 - Heart-on-a-chip (HoC) devices have emerged as a powerful tool for studying the human heart's intricate functions and dysfunctions in vitro. Traditional preclinical models, such as 2D cell cultures model and animal model, have limitations in accurately predicting human response to cardiovascular diseases and treatments. The HoC approach addresses these shortcomings by recapitulating the microscale anatomy, physiology, and biomechanics of the heart, thereby providing a more clinically relevant platform for drug testing, disease modeling, and personalized therapy. Recent years have seen significant strides in HoC technology, driven by advancements in biomaterials, bioelectronics, and tissue engineering. Here, we first review the construction and on-chip detection in HoC. Then we introduce the current proceedings of in vitro models for studying cardiovascular diseases (CVD) based on the HoC platform, including ischemia and myocardial infarction, cardiac fibrosis, cardiac scar, myocardial hypertrophy and other CVD models. Finally, we discuss the future directions of HoC and related emerging technologies.
PY - 2025
EP - 132
ST - Heart-on-a-chip
T2 - Journal of Translational Medicine
TI - Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling
UR - https://doi.org/10.1186/s12967-024-05986-y
VL - 23
Y2 - 2025-02-05
SN - 1479-5876
ER -