TY - JOUR
KW - AD biomarkers
KW - Alzheimer’s disease (AD)
KW - Blood–brain barrier (BBB)
KW - microfluidic chips
KW - three-dimensional AD model
AU - Yan Li
AU - Danni Li
AU - Pei Zhao
AU - Krishnaswamy Nandakumar
AU - Liqiu Wang
AU - Youqiang Song
AB - Early detection and accurate diagnosis of Alzheimer’s disease (AD) is essential for patient care and disease treatment. Microfluidic technology is emerging as an economical and versatile platform in disease detection and diagnosis. It can be conveniently integrated with nanotechnology and/or biological models for biomedical functional and pre-clinical treatment study. These strengths make it advantageous in disease biomarker detection and functional analysis against a wide range of biological backgrounds. This review highlights the recent developments and trends of microfluidic applications in AD research. The first part looks at the principles and methods for AD diagnostic biomarker detection and profiling. The second part discusses how microfluidic chips, especially organ-on-a-chip platforms, could be used as an independent approach and/or integrated with other technologies in AD biomimetic functional analysis.
BT - Micromachines
DA - 2020/9
DO - 10.3390/mi11090787
IS - 9
LA - en
N2 - Early detection and accurate diagnosis of Alzheimer’s disease (AD) is essential for patient care and disease treatment. Microfluidic technology is emerging as an economical and versatile platform in disease detection and diagnosis. It can be conveniently integrated with nanotechnology and/or biological models for biomedical functional and pre-clinical treatment study. These strengths make it advantageous in disease biomarker detection and functional analysis against a wide range of biological backgrounds. This review highlights the recent developments and trends of microfluidic applications in AD research. The first part looks at the principles and methods for AD diagnostic biomarker detection and profiling. The second part discusses how microfluidic chips, especially organ-on-a-chip platforms, could be used as an independent approach and/or integrated with other technologies in AD biomimetic functional analysis.
PY - 2020
EP - 787
T2 - Micromachines
TI - Microfluidics-Based Systems in Diagnosis of Alzheimer’s Disease and Biomimetic Modeling
UR - https://www.mdpi.com/2072-666X/11/9/787
VL - 11
Y2 - 2024-11-26
SN - 2072-666X
ER -