TY - JOUR
KW - Biomedical Engineering
KW - High-throughput screening
KW - reprogramming
KW - Stem-cell biotechnology
KW - Tissue engineering
AU - Patricia R. Pitrez
AU - Luis M. Monteiro
AU - Oliver Borgogno
AU - Xavier Nissan
AU - Jerome Mertens
AU - Lino Ferreira
AB - The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions.
BT - Nature Communications
DA - 2024-02-28
DO - 10.1038/s41467-024-46004-5
IS - 1
LA - en
N2 - The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions.
PY - 2024
EP - 1816
T2 - Nature Communications
TI - Cellular reprogramming as a tool to model human aging in a dish
UR - https://www.nature.com/articles/s41467-024-46004-5
VL - 15
Y2 - 2024-11-26
SN - 2041-1723
ER -