TY - JOUR
KW - Cognitive neuroscience
KW - Computational neuroscience
KW - Diseases of the nervous system
KW - Magnetic Resonance Imaging
KW - translational research
AU - Nicolas Boulant
AU - Franck Mauconduit
AU - Vincent Gras
AU - Alexis Amadon
AU - Caroline Le Ster
AU - Michel Luong
AU - Aurélien Massire
AU - Christophe Pallier
AU - Laure Sabatier
AU - Michel Bottlaender
AU - Alexandre Vignaud
AU - Denis Le Bihan
AB - The understanding of the human brain is one of the main scientific challenges of the twenty-first century. In the early 2000s, the French Atomic Energy Commission launched a program to conceive and build a human magnetic resonance imaging scanner operating at 11.7 T. We have now acquired human brain images in vivo at such a magnetic field. We deployed parallel transmission tools to mitigate the radiofrequency field inhomogeneity problem and tame the specific absorption rate. The safety of human imaging at such high field strength was demonstrated using physiological, vestibular, behavioral and genotoxicity measurements on the imaged volunteers. Our technology yields T2 and T2*-weighted images reaching mesoscale resolutions within short acquisition times and with a high signal and contrast-to-noise ratio.
BT - Nature Methods
DA - 2024-11
DO - 10.1038/s41592-024-02472-7
IS - 11
LA - en
N2 - The understanding of the human brain is one of the main scientific challenges of the twenty-first century. In the early 2000s, the French Atomic Energy Commission launched a program to conceive and build a human magnetic resonance imaging scanner operating at 11.7 T. We have now acquired human brain images in vivo at such a magnetic field. We deployed parallel transmission tools to mitigate the radiofrequency field inhomogeneity problem and tame the specific absorption rate. The safety of human imaging at such high field strength was demonstrated using physiological, vestibular, behavioral and genotoxicity measurements on the imaged volunteers. Our technology yields T2 and T2*-weighted images reaching mesoscale resolutions within short acquisition times and with a high signal and contrast-to-noise ratio.
PY - 2024
SP - 2013
EP - 2016
T2 - Nature Methods
TI - In vivo imaging of the human brain with the Iseult 11.7-T MRI scanner
UR - https://www.nature.com/articles/s41592-024-02472-7
VL - 21
Y2 - 2024-11-12
SN - 1548-7105
ER -