TY - JOUR
KW - Cell biology
KW - induced pluripotent stem cells
KW - Parkinson's disease
KW - Stem-cell biotechnology
AU - Xin Cui
AU - Xinwei Li
AU - Huimin Zheng
AU - Yun Su
AU - Shuyu Zhang
AU - Mengjie Li
AU - Xiaoyan Hao
AU - Shuo Zhang
AU - Zhengwei Hu
AU - Zongping Xia
AU - Changhe Shi
AU - Yuming Xu
AU - Chengyuan Mao
AB - Parkinson’s disease (PD) is a neurodegenerative disorder marked by the loss of dopaminergic neurons in the substantia nigra. Despite progress, the pathogenesis remains unclear. Human midbrain organoids (hMLOs) have emerged as a promising model for studying PD, drug screening, and potential treatments. This review discusses the development of hMLOs, their application in PD research, and current challenges in organoid construction, highlighting possible optimization strategies.
BT - npj Parkinson's Disease
DA - 2024-10-20
DO - 10.1038/s41531-024-00799-8
IS - 1
LA - en
N2 - Parkinson’s disease (PD) is a neurodegenerative disorder marked by the loss of dopaminergic neurons in the substantia nigra. Despite progress, the pathogenesis remains unclear. Human midbrain organoids (hMLOs) have emerged as a promising model for studying PD, drug screening, and potential treatments. This review discusses the development of hMLOs, their application in PD research, and current challenges in organoid construction, highlighting possible optimization strategies.
PY - 2024
SP - 1
EP - 14
ST - Human midbrain organoids
T2 - npj Parkinson's Disease
TI - Human midbrain organoids: a powerful tool for advanced Parkinson’s disease modeling and therapy exploration
UR - https://www.nature.com/articles/s41531-024-00799-8
VL - 10
Y2 - 2024-10-21
SN - 2373-8057
ER -