TY - RPRT
AU - Valerie Zuang
AU - João Barroso
AU - Elisabet Berggren
AU - Stephanie Bopp
AU - Sara Bridio
AU - Silvia Casati
AU - Raffaella Corvi
AU - Pierre Deceuninck
AU - Antonio Franco
AU - Annalisa Gastaldello
AU - Ingrid Langezaal
AU - Julia Malinowska
AU - Milena Mennecozzi
AU - Anne Milcamps
AU - Sharon Munn
AU - Monica Piergiovanni
AU - Pilar Prieto-Peraita
AU - Stavroula Sampani
AU - Debora Valsesia
AU - Maurice Whelan
AU - Clemens Wittwehr
AU - Andrew Worth
AB - The 2023 EURL ECVAM Status Report outlines research and development activities, along with initiatives that foster the implementation and utilisation of non-animal methods and approaches in scientific research and regulation. The Three Rs principle, which advocates for Replacement, Reduction, and Refinement of animal use in basic, applied, and translational research, as well as for regulatory purposes, is firmly established in EU legislation, with the ultimate goal of fully replacing animal testing.
New approach methodologies encompassing a range of innovative technologies, including in vitro methods employing 3D tissues and cells, organ-on-chip technologies, computational models (including machine learning and artificial intelligence), and 'omics (transcriptomics and metabolomics), are developed, evaluated, and integrated into assessment frameworks in order to enhance the efficiency and effectiveness of hazard and risk assessment of chemicals and products across various regulatory contexts. Furthermore, substantial efforts are directed at promoting the development and utilisation of non-animal approaches in fundamental and applied research, where the majority of animal testing occurs, as well as for educational purposes. The achievements and accomplishments documented in this report are the culmination of collaborative efforts with EURL ECVAM's dedicated partners and stakeholders.
CY - Luxembourg
DA - 2024/03/12
LA - en
N2 - The 2023 EURL ECVAM Status Report outlines research and development activities, along with initiatives that foster the implementation and utilisation of non-animal methods and approaches in scientific research and regulation. The Three Rs principle, which advocates for Replacement, Reduction, and Refinement of animal use in basic, applied, and translational research, as well as for regulatory purposes, is firmly established in EU legislation, with the ultimate goal of fully replacing animal testing.
New approach methodologies encompassing a range of innovative technologies, including in vitro methods employing 3D tissues and cells, organ-on-chip technologies, computational models (including machine learning and artificial intelligence), and 'omics (transcriptomics and metabolomics), are developed, evaluated, and integrated into assessment frameworks in order to enhance the efficiency and effectiveness of hazard and risk assessment of chemicals and products across various regulatory contexts. Furthermore, substantial efforts are directed at promoting the development and utilisation of non-animal approaches in fundamental and applied research, where the majority of animal testing occurs, as well as for educational purposes. The achievements and accomplishments documented in this report are the culmination of collaborative efforts with EURL ECVAM's dedicated partners and stakeholders.
PB - European Union
PP - Luxembourg
PY - 2024
TI - Non-Animal Methods in Science and Regulation
UR - https://publications.jrc.ec.europa.eu/repository/handle/JRC136460
Y2 - 2024-08-13
SN - JRC136460
ER -