TY - JOUR
KW - BBB-on-a-chip
KW - Blood–brain barrier
KW - microfluidics
KW - Neurovascular unit
KW - Stroke
AU - Nienke R. Wevers
AU - Arya Lekshmi Nair
AU - Tania M. Fowke
AU - Maria Pontier
AU - Dhanesh G. Kasi
AU - Xandor M. Spijkers
AU - Charlie Hallard
AU - Gwenaëlle Rabussier
AU - Remko van Vught
AU - Paul Vulto
AU - Helga E. de Vries
AU - Henriëtte L. Lanz
AB - In ischemic stroke, the function of the cerebral vasculature is impaired. This vascular structure is formed by the so-called neurovascular unit (NVU). A better understanding of the mechanisms involved in NVU dysfunction and recovery may lead to new insights for the development of highly sought therapeutic approaches. To date, there remains an unmet need for complex human in vitro models of the NVU to study ischemic events seen in the human brain.
BT - Fluids and Barriers of the CNS
DA - 2021-12-14
DO - 10.1186/s12987-021-00294-9
N2 - In ischemic stroke, the function of the cerebral vasculature is impaired. This vascular structure is formed by the so-called neurovascular unit (NVU). A better understanding of the mechanisms involved in NVU dysfunction and recovery may lead to new insights for the development of highly sought therapeutic approaches. To date, there remains an unmet need for complex human in vitro models of the NVU to study ischemic events seen in the human brain.
PY - 2021
EP - 59
T2 - Fluids and Barriers of the CNS
TI - Modeling ischemic stroke in a triculture neurovascular unit on-a-chip
UR - https://doi.org/10.1186/s12987-021-00294-9
VL - 18
Y2 - 2024-08-13
SN - 2045-8118
ER -