TY - JOUR
KW - AI drug discovery
KW - AI drug in clinical trials
KW - AI-discovered drug
KW - AI-native Biotech
KW - Clinical trial success rate
AU - Madura KP Jayatunga
AU - Margaret Ayers
AU - Lotte Bruens
AU - Dhruv Jayanth
AU - Christoph Meier
AB - AI techniques are making inroads into the field of drug discovery. As a result, a growing number of drugs and vaccines have been discovered using AI. However, questions remain about the success of these molecules in clinical trials. To address these questions, we conducted a first analysis of the clinical pipelines of AI-native Biotech companies. In Phase I we find AI-discovered molecules have an 80–90% success rate, substantially higher than historic industry averages. This suggests, we argue, that AI is highly capable of designing or identifying molecules with drug-like properties. In Phase II the success rate is ∼40%, albeit on a limited sample size, comparable to historic industry averages. Our findings highlight early signs of the clinical potential of AI-discovered molecules.
BT - Drug Discovery Today
DA - 2024-06-01
DO - 10.1016/j.drudis.2024.104009
IS - 6
N2 - AI techniques are making inroads into the field of drug discovery. As a result, a growing number of drugs and vaccines have been discovered using AI. However, questions remain about the success of these molecules in clinical trials. To address these questions, we conducted a first analysis of the clinical pipelines of AI-native Biotech companies. In Phase I we find AI-discovered molecules have an 80–90% success rate, substantially higher than historic industry averages. This suggests, we argue, that AI is highly capable of designing or identifying molecules with drug-like properties. In Phase II the success rate is ∼40%, albeit on a limited sample size, comparable to historic industry averages. Our findings highlight early signs of the clinical potential of AI-discovered molecules.
PY - 2024
EP - 104009
ST - How successful are AI-discovered drugs in clinical trials?
T2 - Drug Discovery Today
TI - How successful are AI-discovered drugs in clinical trials? A first analysis and emerging lessons
UR - https://www.sciencedirect.com/science/article/pii/S135964462400134X
VL - 29
Y2 - 2024-08-05
SN - 1359-6446
ER -