TY - JOUR
KW - chronic wounds
KW - hypertrophic scars
KW - in vitro skin models
KW - in vitro wound healing
KW - keloids
AU - Elisabeth Hofmann
AU - Julia Fink
AU - Anna-Lisa Pignet
AU - Anna Schwarz
AU - Marlies Schellnegger
AU - Sebastian P. Nischwitz
AU - Judith C. J. Holzer-Geissler
AU - Lars-Peter Kamolz
AU - Petra Kotzbeck
AB - Skin wound healing is essential to health and survival. Consequently, high amounts of research effort have been put into investigating the cellular and molecular components involved in the wound healing process. The use of animal experiments has contributed greatly to the knowledge of wound healing, skin diseases, and the exploration of treatment options. However, in addition to ethical concerns, anatomical and physiological inter-species differences often influence the translatability of animal-based studies. Human in vitro skin models, which include essential cellular and structural components for wound healing analyses, would improve the translatability of results and reduce animal experiments during the preclinical evaluation of novel therapy approaches. In this review, we summarize in vitro approaches, which are used to study wound healing as well as wound healing-pathologies such as chronic wounds, keloids, and hypertrophic scars in a human setting.
BT - Biomedicines
DA - 2023/4
DO - 10.3390/biomedicines11041056
IS - 4
LA - en
N2 - Skin wound healing is essential to health and survival. Consequently, high amounts of research effort have been put into investigating the cellular and molecular components involved in the wound healing process. The use of animal experiments has contributed greatly to the knowledge of wound healing, skin diseases, and the exploration of treatment options. However, in addition to ethical concerns, anatomical and physiological inter-species differences often influence the translatability of animal-based studies. Human in vitro skin models, which include essential cellular and structural components for wound healing analyses, would improve the translatability of results and reduce animal experiments during the preclinical evaluation of novel therapy approaches. In this review, we summarize in vitro approaches, which are used to study wound healing as well as wound healing-pathologies such as chronic wounds, keloids, and hypertrophic scars in a human setting.
PY - 2023
EP - 1056
T2 - Biomedicines
TI - Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders
UR - https://www.mdpi.com/2227-9059/11/4/1056
VL - 11
Y2 - 2024-07-30
SN - 2227-9059
ER -