TY - JOUR
AU - Elizabeth Footner
AU - Kate Firipis
AU - Emily Liu
AU - Chris Baker
AU - Peter Foley
AU - Robert M. I. Kapsa
AU - Elena Pirogova
AU - Cathal O’Connell
AU - Anita Quigley
AB - In vitro human skin models are evolving into versatile platforms for the study of skin biology and disorders. These models have many potential applications in the fields of drug testing and safety assessment, as well as cosmetic and new treatment development. The development of in vitro skin models that accurately mimic native human skin can reduce reliance on animal models and also allow for more precise, clinically relevant testing. Recent advances in biofabrication techniques and biomaterials have led to the creation of increasingly complex, multilayered skin models that incorporate important functional components of skin, such as the skin barrier, mechanical properties, pigmentation, vasculature, hair follicles, glands, and subcutaneous layer. This improved ability to recapitulate the functional aspects of native skin enhances the ability to model the behavior and response of native human skin, as the complex interplay of cell-to-cell and cell-to-material interactions are incorporated. In this review, we summarize the recent developments in in vitro skin models, with a focus on their applications, limitations, and future directions.
BT - ACS Biomaterials Science & Engineering
DA - 2023-11-13
DO - 10.1021/acsbiomaterials.3c00283
IS - 11
N2 - In vitro human skin models are evolving into versatile platforms for the study of skin biology and disorders. These models have many potential applications in the fields of drug testing and safety assessment, as well as cosmetic and new treatment development. The development of in vitro skin models that accurately mimic native human skin can reduce reliance on animal models and also allow for more precise, clinically relevant testing. Recent advances in biofabrication techniques and biomaterials have led to the creation of increasingly complex, multilayered skin models that incorporate important functional components of skin, such as the skin barrier, mechanical properties, pigmentation, vasculature, hair follicles, glands, and subcutaneous layer. This improved ability to recapitulate the functional aspects of native skin enhances the ability to model the behavior and response of native human skin, as the complex interplay of cell-to-cell and cell-to-material interactions are incorporated. In this review, we summarize the recent developments in in vitro skin models, with a focus on their applications, limitations, and future directions.
PY - 2023
SP - 5933
EP - 5952
T2 - ACS Biomaterials Science & Engineering
TI - Layer-by-Layer Analysis of In Vitro Skin Models
UR - https://doi.org/10.1021/acsbiomaterials.3c00283
VL - 9
Y2 - 2024-07-30
ER -