TY - JOUR
KW - Communicable Diseases
KW - Humans
KW - infection
KW - Liver
KW - Lung
KW - Microfluidic device
KW - microphysiological systems
KW - organ-on-a-chip
KW - virus
KW - bacteria
AU - Fuki Yokoi
AU - Sayaka Deguchi
AU - Kazuo Takayama
AB - Infectious diseases are caused by the invasion of pathogens into a host. To explore the mechanisms of pathogen infections and cellular responses, human models that can accurately recapitulate human pathophysiology are needed. Organ-on-a-chip is a type of advanced in vitro model system that cultures cells in microfluidic devices to replicate physiologically relevant microenvironments such as 3D structures, shear stress, and mechanical stimulation. Recently, organ-on-a-chips have been widely adopted to examine the pathophysiology of infectious diseases in detail. Here, we will summarize recent advances in infectious disease research of visceral organs such as the lung, intestine, liver, and kidneys, using organ-on-a-chips.
BT - Biochimica Et Biophysica Acta. Molecular Cell Research
DA - 2023-08
DO - 10.1016/j.bbamcr.2023.119504
IS - 6
LA - eng
N2 - Infectious diseases are caused by the invasion of pathogens into a host. To explore the mechanisms of pathogen infections and cellular responses, human models that can accurately recapitulate human pathophysiology are needed. Organ-on-a-chip is a type of advanced in vitro model system that cultures cells in microfluidic devices to replicate physiologically relevant microenvironments such as 3D structures, shear stress, and mechanical stimulation. Recently, organ-on-a-chips have been widely adopted to examine the pathophysiology of infectious diseases in detail. Here, we will summarize recent advances in infectious disease research of visceral organs such as the lung, intestine, liver, and kidneys, using organ-on-a-chips.
PY - 2023
EP - 119504
T2 - Biochimica Et Biophysica Acta. Molecular Cell Research
TI - Organ-on-a-chip models for elucidating the cellular biology of infectious diseases
VL - 1870
SN - 1879-2596
ER -