TY - JOUR
KW - Cell Culture Techniques
KW - Humans
KW - microphysiological systems
KW - organoids
KW - Quality Control
KW - Reproducibility of Results
KW - criteria
KW - in vitro
KW - microphysiological systems
KW - organ on chip
KW - organoids
KW - Quality Control
KW - recommendations
KW - reproducibility
KW - spheroids
KW - Standards
AU - David Pamies
AU - Jason Ekert
AU - Marie-Gabrielle Zurich
AU - Olivier Frey
AU - Sophie Werner
AU - Monica Piergiovanni
AU - Benjamin S. Freedman
AU - Adrian Kee Keong Teo
AU - Hendrik Erfurth
AU - Darwin R. Reyes
AU - Peter Loskill
AU - Pelin Candarlioglu
AU - Laura Suter-Dick
AU - Shan Wang
AU - Thomas Hartung
AU - Sandra Coecke
AU - Glyn N. Stacey
AU - Beren Atac Wagegg
AU - Eva-Maria Dehne
AU - Francesca Pistollato
AU - Marcel Leist
AB - Cell culture technology has evolved, moving from single-cell and monolayer methods to 3D models like reaggregates, spheroids, and organoids, improved with bioengineering like microfabrication and bioprinting. These advancements, termed microphysiological systems (MPSs), closely replicate tissue environments and human physiology, enhancing research and biomedical uses. However, MPS complexity introduces standardization challenges, impacting reproducibility and trust. We offer guidelines for quality management and control criteria specific to MPSs, facilitating reliable outcomes without stifling innovation. Our fit-for-purpose recommendations provide actionable advice for achieving consistent MPS performance.
BT - Stem Cell Reports
DA - 2024-05-14
DO - 10.1016/j.stemcr.2024.03.009
IS - 5
LA - eng
N2 - Cell culture technology has evolved, moving from single-cell and monolayer methods to 3D models like reaggregates, spheroids, and organoids, improved with bioengineering like microfabrication and bioprinting. These advancements, termed microphysiological systems (MPSs), closely replicate tissue environments and human physiology, enhancing research and biomedical uses. However, MPS complexity introduces standardization challenges, impacting reproducibility and trust. We offer guidelines for quality management and control criteria specific to MPSs, facilitating reliable outcomes without stifling innovation. Our fit-for-purpose recommendations provide actionable advice for achieving consistent MPS performance.
PY - 2024
SP - 604
EP - 617
T2 - Stem Cell Reports
TI - Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility
VL - 19
SN - 2213-6711
ER -