TY - JOUR
KW - animal models
KW - Biomedical Research
KW - human-centric methodologies
KW - policy
KW - public health challenges
KW - systemic thinking
AU - Helder Constantino
AU - Francesca Pistollato
AU - Troy Seidle
AB - Human-centric methodologies like microphysiological systems and in silico methods have shown promise in addressing the limitations of animal models in understanding human biology and responding to public health priorities. However, the prevailing paradigm based on animal research persists. The article proposes a systemic thinking approach, endorsed by the OECD and the EU, as a tool to leverage innovation to reframe the issue and achieve transformative policies. By identifying the complex factors shaping method selection in basic and biomedical research, a simplified model is presented to illuminate the systemic nature of this decision-making process. The goal is not to prescribe solutions but to offer policymakers a new framework for more-effective strategies, emphasizing collaboration among stakeholders and the need for robust data.
BT - Drug Discovery Today
DA - 2024-03-21
DO - 10.1016/j.drudis.2024.103947
IS - 4
N2 - Human-centric methodologies like microphysiological systems and in silico methods have shown promise in addressing the limitations of animal models in understanding human biology and responding to public health priorities. However, the prevailing paradigm based on animal research persists. The article proposes a systemic thinking approach, endorsed by the OECD and the EU, as a tool to leverage innovation to reframe the issue and achieve transformative policies. By identifying the complex factors shaping method selection in basic and biomedical research, a simplified model is presented to illuminate the systemic nature of this decision-making process. The goal is not to prescribe solutions but to offer policymakers a new framework for more-effective strategies, emphasizing collaboration among stakeholders and the need for robust data.
PY - 2024
EP - 103947
ST - Transitioning biomedical research toward human-centric methodologies
T2 - Drug Discovery Today
TI - Transitioning biomedical research toward human-centric methodologies: systems-based strategies
UR - https://www.sciencedirect.com/science/article/pii/S1359644624000722
VL - 29
Y2 - 2024-03-28
SN - 1359-6446
ER -