TY - JOUR KW - Biomedical Research KW - Black or African American KW - Humans KW - National Institutes of Health (U.S.) KW - Peer Review, Research KW - Race Factors KW - Racism KW - Research Personnel KW - Research Support as Topic KW - United States KW - Computational Biology KW - disparities KW - Funding KW - government KW - none KW - peer review KW - policy KW - systems biology AU - Michael S. Lauer AU - Jamie Doyle AU - Joy Wang AU - Deepshikha Roychowdhury AB - A previous report found an association of topic choice with race-based funding disparities among R01 applications submitted to the National Institutes of Health ('NIH') between 2011 and 2015. Applications submitted by African American or Black ('AAB') Principal Investigators ('PIs') skewed toward a small number of topics that were less likely to be funded (or 'awarded'). It was suggested that lower award rates may be related to topic-related biases of peer reviewers. However, the report did not account for differential funding ecologies among NIH Institutes and Centers ('ICs'). In a re-analysis, we find that 10% of 148 topics account for 50% of applications submitted by AAB PIs. These applications on 'AAB Preferred' topics were funded at lower rates, but peer review outcomes were similar. The lower rate of funding for these topics was primarily due to their assignment to ICs with lower award rates, not to peer-reviewer preferences. BT - eLife DA - 2021-04-30 DO - 10.7554/eLife.67173 LA - eng N2 - A previous report found an association of topic choice with race-based funding disparities among R01 applications submitted to the National Institutes of Health ('NIH') between 2011 and 2015. Applications submitted by African American or Black ('AAB') Principal Investigators ('PIs') skewed toward a small number of topics that were less likely to be funded (or 'awarded'). It was suggested that lower award rates may be related to topic-related biases of peer reviewers. However, the report did not account for differential funding ecologies among NIH Institutes and Centers ('ICs'). In a re-analysis, we find that 10% of 148 topics account for 50% of applications submitted by AAB PIs. These applications on 'AAB Preferred' topics were funded at lower rates, but peer review outcomes were similar. The lower rate of funding for these topics was primarily due to their assignment to ICs with lower award rates, not to peer-reviewer preferences. PY - 2021 EP - e67173 T2 - eLife TI - Associations of topic-specific peer review outcomes and institute and center award rates with funding disparities at the National Institutes of Health VL - 10 SN - 2050-084X ER -