TY - JOUR
KW - Europe
KW - Humans
KW - Risk Assessment
KW - environmental agents
KW - evidence integration
KW - new approach methodologies
KW - population health
KW - Risk Assessment
AU - Daniel Krewski
AU - Patrick Saunders-Hastings
AU - Robert A. Baan
AU - Tara S. Barton-Maclaren
AU - Patience Browne
AU - Weihsueh A. Chiu
AU - Maureen Gwinn
AU - Thomas Hartung
AU - Andrew D. Kraft
AU - Juleen Lam
AU - R. Jeffrey Lewis
AU - Moez Sanaa
AU - Rebecca L. Morgan
AU - Greg Paoli
AU - Lorenz Rhomberg
AU - Andrew Rooney
AU - Salomon Sand
AU - Holger J. Schünemann
AU - Kurt Straif
AU - Kristina A. Thayer
AU - Katya Tsaioun
AB - Assessment of potential human health risks associated with environmental and other agents requires careful evaluation of all available and relevant evidence for the agent of interest, including both data-rich and data-poor agents. With the advent of new approach methodologies in toxicological risk assessment, guidance on integrating evidence from mul-tiple evidence streams is needed to ensure that all available data is given due consideration in both qualitative and quantitative risk assessment. The present report summarizes the discussions among academic, government, and private sector participants from North America and Europe in an international workshop convened to explore the development of an evidence-based risk assessment framework, taking into account all available evidence in an appropriate manner in order to arrive at the best possible characterization of potential human health risks and associated uncertainty. Although consensus among workshop participants was not a specific goal, there was general agreement on the key consider-ations involved in evidence-based risk assessment incorporating 21st century science into human health risk assessment. These considerations have been embodied into an overarching prototype framework for evidence integration that will be explored in more depth in a follow-up meeting.
BT - ALTEX
DA - 2022
DO - 10.14573/altex.2004041
IS - 4
LA - eng
N2 - Assessment of potential human health risks associated with environmental and other agents requires careful evaluation of all available and relevant evidence for the agent of interest, including both data-rich and data-poor agents. With the advent of new approach methodologies in toxicological risk assessment, guidance on integrating evidence from mul-tiple evidence streams is needed to ensure that all available data is given due consideration in both qualitative and quantitative risk assessment. The present report summarizes the discussions among academic, government, and private sector participants from North America and Europe in an international workshop convened to explore the development of an evidence-based risk assessment framework, taking into account all available evidence in an appropriate manner in order to arrive at the best possible characterization of potential human health risks and associated uncertainty. Although consensus among workshop participants was not a specific goal, there was general agreement on the key consider-ations involved in evidence-based risk assessment incorporating 21st century science into human health risk assessment. These considerations have been embodied into an overarching prototype framework for evidence integration that will be explored in more depth in a follow-up meeting.
PY - 2022
SP - 667
EP - 693
T2 - ALTEX
TI - Development of an Evidence-Based Risk Assessment Framework
VL - 39
SN - 1868-8551
ER -